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Title: Radiological findings in young children investigated for tuberculosis in mozambique
Author: García-Basteiro, Alberto L.
López-Varela, Elisa
Augusto, Orvalho
Gondo, Kizito
Muñoz, José
Sacarlal, Jahit
Marais, Ben
Alonso, Pedro
Ribo Aristizabal, Jose Luis
Keywords: Tuberculosi
Diagnòstic radiològic
Malalties dels infants
Radioscopic diagnosis
Children's diseases
Issue Date: 28-May-2015
Publisher: Public Library of Science (PLoS)
Abstract: INTRODUCTION: Chest radiography remains a critical tool for diagnosing intrathoracic tuberculosis (TB) in young children who are unable to expectorate. We describe the radiological findings in children under 3 years of age investigated for TB in the district of Manhica, southern Mozambique, an area with a high prevalence of TB and HIV. METHODS: Digital antero-posterior and lateral projections were performed and reviewed by two independent readers, using a standardized template. Readers included a local pediatrician and a pediatric radiologist blinded to all clinical information. International consensus case definitions for intra-thoracic TB in children were applied. RESULTS: A total of 766 children were evaluated of whom 43 (5.6%) had TB. The most frequent lesion found in TB cases was air space consolidation (65.1%), followed by suggestive hilar lymphadenopathy (17.1%) and pleural effusion (7.0%). Air space consolidation was significantly more common in TB cases than in non-TB cases (odds ratio 8.9; 95% CI: 1.6-50.5), as were hilar lymphadenopathy (OR 17.2; 95% CI: 5.7-52.1). The only case with miliary infiltrates and 3 with pleural effusions occurred in HIV-infected children. CONCLUSION: Frequent air space consolidation complicates radiological distinction between TB and bacterial pneumonia in young children, underscoring the need for epidemiological contextualization and consideration of all relevant signs and symptoms.
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It is part of: PloS one, 2015, vol. 10, num. 5, p. e0127323
Correction: PLoS ONE, 2015, 10(5): e0127323
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Medicina)

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