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Title: Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis
Author: Teruel, María
McKinney, Cushla
Balsa, Alejandro
Pascual-Salcedo, Dora
Rodríguez-Rodríguez, Luis
Ortiz, Ana M.
Gómez Vaquero, Carmen
González-Gay, Miguel A.
Smith, Malcolm
Witte, Torsten
Merriman, Tony
Lie, Benedicte A.
Martín, Javier
Keywords: Artritis reumatoide
Genoma humà
Malalties autoimmunitàries
Cèl·lules T
Rheumatoid arthritis
Human genome
Autoimmune diseases
T cells
Issue Date: 1-Jul-2013
Publisher: Public Library of Science (PLoS)
Abstract: Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10−10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2013, vol. 8, num. 7, p. e68295
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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