Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69634
Title: Flower development as an interplay between dynamical physical field and genetic networks
Author: Barrio, Rafael Ángel
Hernández Machado, Aurora
Varea, C.
Romero-Arias, José Roberto
Alvarez-Buylla, Elena
Keywords: Morfogènesi
Desenvolupament de les plantes
Flors
Diferenciació cel·lular
Arabidopsis thaliana
Morphogenesis
Plant development
Flowers
Cell diferentiation
Arabidopsis thaliana
Issue Date: 27-Oct-2010
Publisher: Public Library of Science (PLoS)
Abstract: In this paper we propose a model to describe the mechanisms by which undifferentiated cells attain gene configurations underlying cell fate determination during morphogenesis. Despite the complicated mechanisms that surely intervene in this process, it is clear that the fundamental fact is that cells obtain spatial and temporal information that bias their destiny. Our main hypothesis assumes that there is at least one macroscopic field that breaks the symmetry of space at a given time. This field provides the information required for the process of cell differentiation to occur by being dynamically coupled to a signal transduction mechanism that, in turn, acts directly upon the gene regulatory network (GRN) underlying cell-fate decisions within cells. We illustrate and test our proposal with a GRN model grounded on experimental data for cell fate specification during organ formation in early Arabidopsis thaliana flower development. We show that our model is able to recover the multigene configurations characteristic of sepal, petal, stamen and carpel primordial cells arranged in concentric rings, in a similar pattern to that observed during actual floral organ determination. Such pattern is robust to alterations of the model parameters and simulated failures predict altered spatio-temporal patterns that mimic those described for several mutants. Furthermore, simulated alterations in the physical fields predict a pattern equivalent to that found in Lacandonia schismatica, the only flowering species with central stamens surrounded by carpels.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0013523
It is part of: PLoS One, 2010, vol. 5, num. 10, p. e13523-e13523
Related resource: http://dx.doi.org/10.1371/journal.pone.0013523
URI: http://hdl.handle.net/2445/69634
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Física Quàntica i Astrofísica)

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