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Title: The urea cycle of rat white adipose tissue
Author: Arriarán, Sofía
Agnelli, Silvia
Remesar Betlloch, Xavier
Fernández López, José Antonio
Alemany, Marià, 1946-
Keywords: Urea
Teixit adipós
Rates (Animals de laboratori)
Adipose tissues
Amino acids
Rats as laboratory animals
Issue Date: 19-Oct-2015
Publisher: Royal Society of Chemistry
Abstract: White adipose tissue (WAT) contains a powerful metabolic machinery related to energy metabolism and partition. The adaptive, regulatory, size and structural variety of WAT agrees with this control role. However, its nitrogen metabolism has been sparsely studied and we know close to nothing about its implication on N-related processes and homoeostasis. We have studied, and found a complete urea cycle (liver type) in four WAT sites (gene expressions and enzyme activities). We postulated a possible function of the cycle (under basal conditions) in the control of arginine handling through citrulline synthesis. In our opinion, the metabolic and control potential of WAT on energy metabolism is second only to liver. This impression should be extended to amino acid metabolism too, WAT providing an extra-intestinal source of citrulline to maintain the body availability of arginine independently of the operation of intestine-liver urea cycle for N disposal.
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It is part of: RSC Advances, 2015, vol. 5, num. 113, p. 93403-93414
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ISSN: 2046-2069
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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