Dipòsit Digital de la Universitat de Barcelona

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El Dipòsit Digital de la Universitat de Barcelona és el repositori institucional que conté en format digital els materials derivats de l'activitat docent, investigadora i institucional de la comunitat universitària.

Enviaments recents

Plant-derived compounds, vitagens, vitagenes and mitochondrial function
(Elsevier, 2022-03-01) Franco Fernández, Rafael; Navarro Brugal, Gemma; Martínez-Pinilla, Eva
There is great interest in identifying natural products that can be approved as nutraceuticals. A good option is to induce transcription of vitagenes, which would lead to increased expression of proteins that provide the means to maintain homeostasis. In fact, the induction of vitagenes is considered relevant during aging, especially if aging is accompanied by neurodegenerative diseases. Care must be taken to avoid confusing vitagenes, which are genes, and vitagens, which are vitamin-like low-molecular weight compounds; both concepts are recalled here. Although mitochondria are key factors in several chronic diseases of the nervous system, the amount of vitagenes that is associated with better mitochondrial function (bioenergetics, oxidative stress, biogenesis, dynamics, etc.) is limited. Plant molecules have been used for centuries to improve well-being, and some have a directly or indirectly impact on mitochondrial function. However, there is little knowledge about whether plant-derived products can induce vitagenes related to the enhancement of the multiple actions exerted by mitochondria; studies are needed to detect natural plant compounds that increase the transcription of genes related to the function of this cellular organelle. This study is expected to identify new vitagenes whose induction provides benefits in aging and/or neurodegenerative diseases.
Long-term outcomes of cardiac defibrillator implantation in survivors of out-of-hospital cardiac arrest
(Elsevier España, 2021) Izquierdo, Marc; Cepas Guillén, Pedro; Fernández Valledor, Andrea; Diego Soler, Oriol de; Tolosana, José M. (José María); Andrea, Rut
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Survival after OHCA is poor, although it has improved in the last decade because of the availability of public access to defibrillators. European guidelines recommend an implantable cardioverter defibrillator (ICD) in patients with OHCA and a documented ventricular fibrillation in the absence of reversible causes such as acute coronary syndrome (ACS). However, there is limited data available on the use of an ICD in this group of patients.
A Data Analysis Pipeline for Running Training Profiling and Load Monitoring from Consumer Wearables
(2026-06-10) Nicolau Rivas, Víctor; Sala Llonch, Roser; Marco Pascual, Ricardo
[eng] Running is one of the most popular recreational sports, but the training data that consumer wearables generate is rarely used for anything beyond the individual athlete. This project builds a data analysis pipeline for running data collected through the MyAlbatross platform, covering the full process from raw Garmin FIT file parsing to athlete profiling and workload monitoring, with the aim of analysing training behaviour at group level and identifying runner profiles. The pipeline processed 18,239 FIT files from 118 athletes, enriched them with platform metadata, and applied quality control to produce a clean dataset of 8,246 sessions from 102 athletes. It computes session-level features (training load (TRIMP), grade adjusted pace (GAP), heart rate zone distribution, and running dynamics) and aggregates them into athlete-level features over 8 week windows. K-means clustering was applied as a validation step. At session level it produced eight types whose profiles match the categories described in the endurance literature. At athlete level it produced two profiles: one high-volume, low-intensity and consistent, the other lower-volume, higher-intensity and less consistent. The Acute:Chronic Workload Ratio (ACWR) was computed for the 87 athletes with sufficient training history. The clusters separate athletes along volume and intensity, which shows that the features carry information beyond raw load. The pipeline turns consumer wearable data into validated training features that can serve as the analytical foundation for a recommendation system within MyAlbatross. [cat] Córrer és un dels esports recreatius més populars del món, però les dades d'entrenament que generen els dispositius portables (wearables) rarament s'utilitzen més enllà de l'atleta individual. Aquest projecte construeix un flux de treball (pipeline) d'anàlisi de dades per a dades de running recollides a través de la plataforma MyAlbatross. Cobreix el procés complet des del processament de fitxers FIT bruts de Garmin fins als perfils d'atletes i el monitoratge de la càrrega d'entrenament, amb l'objectiu d'analitzar el comportament d'entrenament a nivell de grup i identificar perfils de corredors. El flux de treball ha processat 18.239 fitxers FIT de 118 atletes, els ha enriquit amb dades de la plataforma i ha aplicat control de qualitat per obtenir un conjunt de dades net de 8.246 sessions de 102 atletes. Calcula característiques a nivell de sessió (càrrega d'entrenament (TRIMP), ritme ajustat al pendent (GAP), distribució de zones de freqüència cardíaca i dinàmica de carrera) i les agrega en característiques a nivell d'atleta en finestres de 8 setmanes. L’agrupament (clustering) K-means es va aplicar com a pas de validació. A nivell de sessió va produir vuit tipus els perfils dels quals coincideixen amb les categories descrites a la literatura d'esports de resistència. A nivell d'atleta va produir dos perfils: un d'alt volum, baixa intensitat i consistent, i un altre de menor volum, major intensitat i menys consistent. La relació càrrega aguda:crònica (ACWR) es va calcular per als 87 atletes amb historial d'entrenament suficient. Els clústers separen els atletes per volum i intensitat, cosa que mostra que les característiques contenen informació més enllà del volum d'entrenament. El flux de treball converteix les dades de dispositius portables de consum en característiques d'entrenament validades que poden servir de base analítica per a un sistema de recomanació dins de MyAlbatross.
Assertion: A (partly) social speech act
(Elsevier B.V., 2021-08-01) Marsili, Neri; Green, Mitchell
In a series of articles (Pagin, 2004, 2009), Peter Pagin has argued that assertion is not a social speech act, introducing a method (which we baptize ‘the P-test’) designed to refute any account that defines assertion in terms of its social effects. This paper contends that Pagin's method fails to rebut the thesis that assertion is social. We show that the P-test is both unreliable (because it overgenerates counterexamples) and counterproductive (because it ultimately provides evidence in favor of some social accounts). Nonetheless, we contend that assertion is not fully social. We defend an intermediate view according to which assertion is only a partly social speech act: assertions both commit the speaker to a proposition (a social component) and present their propositional content as true (a non-social component). The upshot is that assertion is in some important respect social, although it cannot be defined solely in terms of its social effects.
Clinical Utility and Evolution of Donor Serum Lactate During Normothermic Regional Perfusion in Uncontrolled Donation After Circulatory Death
(Elsevier B.V., 2021-11-01) Rodríguez, Camino; Paredes, David; Roque, Rebeca; Reinoso, Johanna; Sánchez-Etayo, Gerard
Kidney transplantation from uncontrolled donor after circulatory death (uDCD) showed a higher incidence of delayed graft function and primary failure. The aim of this study was to study basal and kinetic evolution of lactate values in uDCD preserved on normothermic regional perfusion (NRP) as a predictive factor of kidney suitability exposed to prolong ischemic conditions.