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http://hdl.handle.net/2445/101708
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DC Field | Value | Language |
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dc.contributor.author | Teller Amado, Sara | - |
dc.contributor.author | Tahirbegi, Islam Bogachan | - |
dc.contributor.author | Mir Llorente, Mònica | - |
dc.contributor.author | Samitier i Martí, Josep | - |
dc.contributor.author | Soriano i Fradera, Jordi | - |
dc.date.accessioned | 2016-09-09T16:06:04Z | - |
dc.date.available | 2016-09-09T16:06:04Z | - |
dc.date.issued | 2015-11-26 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/101708 | - |
dc.description.abstract | The understanding of the key mechanisms behind human brain deterioration in Alzheimer' disease (AD) is a highly active field of research. The most widespread hypothesis considers a cascade of events initiated by amyloid-β peptide fibrils that ultimately lead to the formation of the lethal amyloid plaques. Recent studies have shown that other agents, in particular magnetite, can also play a pivotal role. To shed light on the action of magnetite and amyloid-β in the deterioration of neuronal circuits, we investigated their capacity to alter spontaneous activity patterns in cultured neuronal networks. Using a versatile experimental platform that allows the parallel monitoring of several cultures, the activity in controls was compared with the one in cultures dosed with magnetite, amyloid-β and magnetite-amyloid-β complex. A prominent degradation in spontaneous activity was observed solely when amyloid-β and magnetite acted together. Our work suggests that magnetite nanoparticles have a more prominent role in AD than previously thought, and may bring new insights in the understanding of the damaging action of magnetite-amyloid-β complex. Our experimental system also offers new interesting perspectives to explore key biochemical players in neurological disorders through a controlled, model system manner. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/srep17261 | - |
dc.relation.ispartof | Scientific Reports, 2015, vol. 5, num. 17261 | - |
dc.relation.uri | http://dx.doi.org/10.1038/srep17261 | - |
dc.rights | cc-by-nc-nd (c) Teller, Sara et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Magnetita | - |
dc.subject.classification | Amiloïdosi | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Magnetite | - |
dc.subject.other | Amyloidosis | - |
dc.title | Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer's disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 655565 | - |
dc.date.updated | 2016-09-09T16:06:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26608215 | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
Files in This Item:
File | Description | Size | Format | |
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655565.pdf | 2.23 MB | Adobe PDF | View/Open |
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