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http://hdl.handle.net/2445/103103
Title: | Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems |
Author: | Rudilla Mateo, Héctor Fusté i Domínguez, Ester Cajal Visa, Yolanda Rabanal Anglada, Francesc Vinuesa Aumedes, Teresa Viñas, Miquel |
Keywords: | Pseudomonas Síntesi de pèptids Pèptids Biofilms Antibiòtics Pseudomonas Peptide synthesis Peptides Biofilms Antibiotics |
Issue Date: | 12-Sep-2016 |
Publisher: | MDPI |
Abstract: | The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules21091223 |
It is part of: | Molecules, 2016, vol. 21, num. 9, p. 1223 |
URI: | http://hdl.handle.net/2445/103103 |
Related resource: | https://doi.org/10.3390/molecules21091223 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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