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http://hdl.handle.net/2445/104289
Title: | Genetic Variants Associated with Colorectal Adenoma Susceptibility |
Author: | Abulí, Anna Castells Garangou, Antoni Bujanda, Luis Lozano Salvatella, Juan José Bessa i Caserras, Xavier Hernández-Munain, Cristina Álvarez Urturi, Cristina Pellisé Urquiza, Maria Esteban-Jurado, Clara Hijona, Elizabeth Burón, Andrea Macià, Francesc Grau Cano, J. (Jaume) Guayta, Rafael (Guayta Escolies) Castellví Bel, Sergi Andreu, Montserrat Trilla García, Antoni PROCOLON Research Group |
Keywords: | Càncer colorectal Genètica humana Estudi de casos Mutació (Biologia) Colonoscòpia Colorectal cancer Human genetics Case studies Mutation (Biology) Colonoscopy |
Issue Date: | 14-Apr-2016 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0153084 |
It is part of: | PLoS One, 2016, vol. 11, num. 4, p. e0153084 |
URI: | http://hdl.handle.net/2445/104289 |
Related resource: | https://doi.org/10.1371/journal.pone.0153084 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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