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Title: | Evidence of neofunctionalization after the duplication of the highly conserved Polycomb group gene Caf1-55 in the obscura group of Drosophila |
Author: | Calvo Martín, Juan Manuel Papaceit Vidal, Montserrat Segarra Robert, Carmen |
Keywords: | Proteïnes Molècules Drosòfila Proteins Molecules Drosophila |
Issue Date: | 17-Jan-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Drosophila CAF1-55 protein is a subunit of the Polycomb repressive complex PRC2 and other protein complexes. It is a multifunctional and evolutionarily conserved protein that participates in nucleosome assembly and remodelling, as well as in the epigenetic regulation of a large set of target genes. Here, we describe and analyze the duplication of Caf1-55 in the obscura group of Drosophila. Paralogs exhibited a strong asymmetry in evolutionary rates, which suggests that they have evolved according to a neofunctionalization process. During this process, the ancestral copy has been kept under steady purifying selection to retain the ancestral function and the derived copy (Caf1-55dup) that originated via a DNA-mediated duplication event ~18 Mya, has been under clear episodic selection. Different maximum likelihood approaches confirmed the action of positive selection, in contrast to relaxed selection, on Caf1-55dup after the duplication. This adaptive process has also taken place more recently during the divergence of D. subobscura and D. guanche. The possible association of this duplication with a previously detected acceleration in the evolutionary rate of three CAF1-55 partners in PRC2 complexes is discussed. Finally, the timing and functional consequences of the Caf1-55 duplication is compared to other duplications of Polycomb genes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/srep40536 |
It is part of: | Scientific Reports, 2017, vol. 7, num. 40536, p. 1-10 |
URI: | http://hdl.handle.net/2445/107388 |
Related resource: | https://doi.org/10.1038/srep40536 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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