Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/107568
Title: | Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop |
Author: | Ripollés, Pablo Marco Pallarés, Josep Alicart, Helena Tempelmann, Claus Rodríguez Fornells, Antoni Noesselt, Toemme |
Keywords: | Hipocamp (Cervell) Memòria Dopamina Imatges per ressonància magnètica Hippocampus (Brain) Memory Dopamine Magnetic resonance imaging |
Issue Date: | 20-Sep-2016 |
Publisher: | eLife Sciences |
Abstract: | Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fMRI-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop) when successfully grasping the meaning of new-words. Importantly, new-words that were better remembered showed increased activation and enhanced functional connectivity between the midbrain, hippocampus, and ventral striatum. Moreover, enhanced emotion-related physiological measures and subjective pleasantness ratings during encoding were associated with remembered new-words after 24 hr. Furthermore, increased subjective pleasantness ratings were also related to new-words remembered after seven days. These results suggest that intrinsic-potentially reward-related-signals, triggered by self-monitoring of correct performance, can promote the storage of new information into long-term memory through the activation of the SN/VTA-Hippocampal loop, possibly via dopaminergic modulation of the midbrain. |
Note: | Reproducció del document publicat a: https://doi.org/10.7554/eLife.17441 |
It is part of: | eLife, 2016, num. 5:e17441, p. 1-35 |
URI: | http://hdl.handle.net/2445/107568 |
Related resource: | https://doi.org/10.7554/eLife.17441 |
ISSN: | 2050-084X |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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