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https://hdl.handle.net/2445/107829| Title: | Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer |
| Author: | Bosch Cartes, Joan Bachs, Jordi Gómez, Antonia M. Griera Farres, Rosa Écija, Marta Amat Tusón, Mercedes |
| Keywords: | Antihistamínics Estructura molecular Síntesi orgànica Antihistamines Molecular structure Organic synthesis |
| Issue Date: | 20-Jul-2012 |
| Publisher: | American Chemical Society |
| Abstract: | Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/jo300925c |
| It is part of: | Journal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344 |
| URI: | https://hdl.handle.net/2445/107829 |
| Related resource: | https://doi.org/10.1021/jo300925c |
| ISSN: | 0022-3263 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 615886.pdf | 266.49 kB | Adobe PDF | View/Open |
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