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http://hdl.handle.net/2445/107829
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DC Field | Value | Language |
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dc.contributor.author | Bosch Cartes, Joan | - |
dc.contributor.author | Bachs, Jordi | - |
dc.contributor.author | Gómez, Antonia M. | - |
dc.contributor.author | Griera Farres, Rosa | - |
dc.contributor.author | Écija, Marta | - |
dc.contributor.author | Amat Tusón, Mercedes | - |
dc.date.accessioned | 2017-03-03T15:44:50Z | - |
dc.date.available | 2017-03-03T15:44:50Z | - |
dc.date.issued | 2012-07-20 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/2445/107829 | - |
dc.description.abstract | Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/jo300925c | - |
dc.relation.ispartof | Journal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344 | - |
dc.relation.uri | https://doi.org/10.1021/jo300925c | - |
dc.rights | (c) American Chemical Society , 2012 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Antihistamínics | - |
dc.subject.classification | Estructura molecular | - |
dc.subject.classification | Síntesi orgànica | - |
dc.subject.other | Antihistamines | - |
dc.subject.other | Molecular structure | - |
dc.subject.other | Organic synthesis | - |
dc.title | Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 615886 | - |
dc.date.updated | 2017-03-03T15:44:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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615886.pdf | 266.49 kB | Adobe PDF | View/Open |
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