Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/107829
Title: | Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer |
Author: | Bosch Cartes, Joan Bachs, Jordi Gómez, Antonia M. Griera Farres, Rosa Écija, Marta Amat Tusón, Mercedes |
Keywords: | Antihistamínics Estructura molecular Síntesi orgànica Antihistamines Molecular structure Organic synthesis |
Issue Date: | 20-Jul-2012 |
Publisher: | American Chemical Society |
Abstract: | Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/jo300925c |
It is part of: | Journal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344 |
URI: | http://hdl.handle.net/2445/107829 |
Related resource: | https://doi.org/10.1021/jo300925c |
ISSN: | 0022-3263 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
615886.pdf | 266.49 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.