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https://hdl.handle.net/2445/110580| Title: | Bike peptides: a ride through the membrane |
| Author: | García Pindado, Júlia Royo, Soledad Teixidó Turà, Meritxell Giralt Lledó, Ernest |
| Keywords: | Síntesi de pèptids Productes naturals Síntesi orgànica Peptide synthesis Natural products Organic synthesis |
| Issue Date: | 16-Mar-2017 |
| Publisher: | John Wiley & Sons |
| Abstract: | Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1002/psc.2993 |
| It is part of: | Journal of Peptide Science, 2017, vol. 23, num. 4, p. 294-302 |
| URI: | https://hdl.handle.net/2445/110580 |
| Related resource: | http://dx.doi.org/10.1002/psc.2993 |
| ISSN: | 1075-2617 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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