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Title: Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
Author: Gandioso, Albert
Massaguer i Vall-llovera, Anna
Villegas, Núria
Salvans, Cándida
Sánchez, Dani
Brun Heath, Isabelle
Marchán Sancho, Vicente
Orozco López, Modesto
Terrazas Martínez, Montserrat
Keywords: RNA
Càncer de mama
Cèl·lules canceroses
Breast cancer
Cancer cells
Issue Date: 13-Feb-2017
Publisher: Royal Society of Chemistry
Abstract: Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines.
Note: Versió postprint del document publicat a:
It is part of: Chemical Communications, 2017, vol. 53, num. 19, p. 2870-2873
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ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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