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http://hdl.handle.net/2445/110712| Title: | Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells |
| Author: | Gandioso, Albert Massaguer i Vall-llovera, Anna Villegas, Núria Salvans, Cándida Sánchez, Dani Brun-Heath, Isabelle Marchán Sancho, Vicente Orozco López, Modesto Terrazas Martínez, Montserrat |
| Keywords: | RNA Pèptids Càncer de mama Cèl·lules canceroses RNA Peptides Breast cancer Cancer cells |
| Issue Date: | 13-Feb-2017 |
| Publisher: | Royal Society of Chemistry |
| Abstract: | Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1039/C6CC10287E |
| It is part of: | Chemical Communications, 2017, vol. 53, num. 19, p. 2870-2873 |
| URI: | http://hdl.handle.net/2445/110712 |
| Related resource: | https://doi.org/10.1039/C6CC10287E |
| ISSN: | 1359-7345 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 667552.pdf | 1.24 MB | Adobe PDF | View/Open |
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