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https://hdl.handle.net/2445/114162| Title: | High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides |
| Author: | Gamba, Ilaria Salvadó, Iria Brissos, Rosa F. Gámez Enamorado, Patrick Brea, José Loza, María Isabel Vázquez, M. Eugenio Vázquez López, Miguel |
| Keywords: | Síntesi de pèptids Física de l'estat sòlid ADN Càncer Peptide synthesis Solid state physics DNA Cancer |
| Issue Date: | 21-Jan-2016 |
| Publisher: | Royal Society of Chemistry |
| Abstract: | We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1039/C5CC07619F |
| It is part of: | Chemical Communications, 2016, vol. 52, num. 6, p. 1234-1237 |
| URI: | https://hdl.handle.net/2445/114162 |
| Related resource: | https://doi.org/10.1039/C5CC07619F |
| ISSN: | 1359-7345 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 656122.pdf | 2.82 MB | Adobe PDF | View/Open |
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