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https://hdl.handle.net/2445/114291| Title: | Dialkylammonium tert-Butylmethylphosphinites: Stable Intermediates for the Synthesis of P-Stereogenic Ligands |
| Author: | Salomó i Prat, Ernest Prades, Amparo Riera i Escalé, Antoni Verdaguer i Espaulella, Xavier |
| Keywords: | Lligands (Bioquímica) Compostos fosforosos Catàlisi asimètrica Ligands (Biochemistry) Phosphorus compounds Enantioselective catalysis |
| Issue Date: | 22-Jun-2017 |
| Publisher: | American Chemical Society |
| Abstract: | The preparation of shelf-stable crystalline salts of tert-butylmethylphosphinous acid borane 1 is described. X-ray analysis of diisopropylammonium tert-butylmethylphosphinite borane 4 revealed the existence of a cyclic hydrogen-bond network in the solid state which accounts for the increased melting point and stability. Dialkylammonium phosphinite boranes are convenient precursors of the chiral tert-butylmethylphosphine fragment. Compound 4 can be directly employed in SN2@P reactions with different nucleophiles to yield valuable P-stereogenic intermediates and ligands. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.joc.7b01180 |
| It is part of: | Journal of Organic Chemistry, 2017 |
| URI: | https://hdl.handle.net/2445/114291 |
| Related resource: | https://doi.org/10.1021/acs.joc.7b01180 |
| ISSN: | 0022-3263 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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|---|---|---|---|---|
| 673028.pdf | 296.38 kB | Adobe PDF | View/Open |
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