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http://hdl.handle.net/2445/116227
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DC Field | Value | Language |
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dc.contributor.author | Moncunill, Gemma | - |
dc.contributor.author | Rosa, Stephen C. de | - |
dc.contributor.author | Ayestaran, Aintzane | - |
dc.contributor.author | Nhabomba, Augusto J. | - |
dc.contributor.author | Mpina, Maximilian | - |
dc.contributor.author | Cohen, Kristen W. | - |
dc.contributor.author | Jairoce, Chenjerai | - |
dc.contributor.author | Rutishauser, Tobias | - |
dc.contributor.author | Campo, Joseph J. | - |
dc.contributor.author | Harezlak, Jaroslaw | - |
dc.contributor.author | Sanz Ródenas, Héctor | - |
dc.contributor.author | Díez-Padrisa, Núria | - |
dc.contributor.author | Williams, Nana Aba | - |
dc.contributor.author | Morris, Daryl | - |
dc.contributor.author | Aponte, John J. | - |
dc.contributor.author | Valim, Clarissa | - |
dc.contributor.author | Daubenberger, Claudia | - |
dc.contributor.author | Dobaño, Carlota, 1969- | - |
dc.contributor.author | McElrath, M.Juliana | - |
dc.date.accessioned | 2017-10-05T11:43:14Z | - |
dc.date.available | 2017-10-05T11:43:14Z | - |
dc.date.issued | 2017-08-23 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116227 | - |
dc.description.abstract | Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine staining and 16-color flow cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated participants (controls) in a pediatric phase III trial in Africa. RTS,S/AS01E-vaccinated children had significantly higher frequencies of CSP- and HBsAg-specific CD4+ T cells producing IL-2, TNF-alpha, and CD40L and HBsAg-specific CD4+ T producing IFN-gamma and IL-17 than baseline and the control group. Vaccine-induced responses were identified in both central and effector memory (EM) compartments. EM CD4+ T cells expressing IL-4 and IL-21 were detected recognizing both vaccine antigens. Consistently higher response rates to both antigens in RTS,S/AS01E-vaccinated than comparator-vaccinated children were observed. RTS,S/AS01E induced polyfunctional CSP- and HBsAg-specific CD4+ T cells, with a greater degree of polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E vaccine induces T cells of higher functional heterogeneity and polyfunctionality than previously characterized. Responses detected in memory CD4+ T cell compartments may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future correlates of immunity studies. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2017.01008 | - |
dc.relation.ispartof | Frontiers in Immunology, 2017, vol. 8, p. 1008 | - |
dc.relation.uri | http://dx.doi.org/10.3389/fimmu.2017.01008 | - |
dc.rights | cc by (c) Moncunill et al. , 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Plasmodium falciparum | - |
dc.subject.classification | Àfrica | - |
dc.subject.other | Malaria | - |
dc.subject.other | Plasmodium falciparum | - |
dc.subject.other | Africa | - |
dc.title | RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-10-04T18:00:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28878775 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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moncunill2017_2684.pdf | 4.32 MB | Adobe PDF | View/Open |
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