Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/116227
Title: RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial
Author: Moncunill Piñas, Gemma
Rosa, Stephen C. de
Ayestaran, Aintzane
Nhabomba, Augusto J.
Mpina, Maximilian
Cohen, Kristen W.
Jairoce, Chenjerai Tobias Sixpence
Rutishauser, Tobias
Campo, Joseph J.
Harezlak, Jaroslaw
Sanz Ródenas, Héctor
Díez-Padrisa, Núria
Williams, Nana Aba
Morris, Daryl
Aponte, John J.
Valim, Clarissa
Daubenberger, Claudia
Dobaño, Carlota, 1969-
McElrath, M.Juliana
Keywords: Malària
Plasmodium falciparum
Àfrica
Malaria
Plasmodium falciparum
Africa
Issue Date: 23-Aug-2017
Publisher: Frontiers Media
Abstract: Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine staining and 16-color flow cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated participants (controls) in a pediatric phase III trial in Africa. RTS,S/AS01E-vaccinated children had significantly higher frequencies of CSP- and HBsAg-specific CD4+ T cells producing IL-2, TNF-alpha, and CD40L and HBsAg-specific CD4+ T producing IFN-gamma and IL-17 than baseline and the control group. Vaccine-induced responses were identified in both central and effector memory (EM) compartments. EM CD4+ T cells expressing IL-4 and IL-21 were detected recognizing both vaccine antigens. Consistently higher response rates to both antigens in RTS,S/AS01E-vaccinated than comparator-vaccinated children were observed. RTS,S/AS01E induced polyfunctional CSP- and HBsAg-specific CD4+ T cells, with a greater degree of polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E vaccine induces T cells of higher functional heterogeneity and polyfunctionality than previously characterized. Responses detected in memory CD4+ T cell compartments may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future correlates of immunity studies.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2017.01008
It is part of: Frontiers in Immunology, 2017, vol. 8, p. 1008
URI: https://hdl.handle.net/2445/116227
Related resource: http://dx.doi.org/10.3389/fimmu.2017.01008
ISSN: 1664-3224
Appears in Collections:Articles publicats en revistes (ISGlobal)

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