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http://hdl.handle.net/2445/118996
Title: | Deep white matter in Huntington's disease |
Author: | Phillips, Owen R. Squitieri, Ferdinando Sánchez Castañeda, Cristina Elifani, Francesca Caltagirone, Carlo Sabatini, Umberto Paola, Margherita di |
Keywords: | Demència Corea de Huntington Malalties neurodegeneratives Dementia Huntington's chorea Neurodegenerative Diseases |
Issue Date: | 23-Oct-2014 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weighted (iron sensitive) imaging. We collected Pre-HD subjects (n = 25), HD patients (n = 25) and healthy control subjects (n = 50). Results revealed increased axial (AD) and radial diffusivity (RD) and iron levels in Pre-HD subjects compared to controls. Fractional anisotropy decreased between the Pre-HD and HD phase and AD/RD increased and although impairment was pervasive in HD, degeneration occurred in a pattern in Pre-HD. Furthermore, iron levels dropped for HD patients. As increased iron levels are associated with remyelination, the data suggests that Pre-HD subjects attempt to repair damaged deep WM years before symptoms occur but this process fails with disease progression. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0109676 |
It is part of: | PLoS One, 2014, vol. 9, num. 10, p. e109676 |
URI: | http://hdl.handle.net/2445/118996 |
Related resource: | https://doi.org/10.1371/journal.pone.0109676 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
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