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http://hdl.handle.net/2445/119078
Title: | Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015 |
Author: | Gupta, Himanshu Macete, Eusebio Víctor Bulo, Helder Salvador, Crizolgo Warsame, Marian Carvalho, Eva Menard, Didier Ringwald, Pascal Bassat Orellana, Quique Enosse, Sonia Mayor Aparicio, Alfredo Gabriel |
Keywords: | Plasmodium falciparum Moçambic Plasmodium falciparum Mozambique |
Issue Date: | Jan-2018 |
Publisher: | Centers for Disease Control and Prevention |
Abstract: | One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collected from 4 sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps polymorphisms and for plasmepsin2 (pfpm2) and pfmdr1 copy numbers. We found multiple copies of pfpm2 in 1.1% of isolates. All isolates carried K13 wild-type alleles (3D7-like), except 4 novel polymorphisms (Leu619Leu, Phe656Ile, Val666Val, Gly690Gly). Prevalence of isolates with pfcrt mutant (K76T) allele was low (2.3%). Prevalence of isolates with pfdhps mutant alleles (A437G and K540E) was >80%, indicating persistence of sulfadoxine/pyrimethamine resistance; however, markers of artemisinin were absent, and markers of piperaquine resistance were low. Piperaquine resistance isolates may spread in Mozambique as dihydroartemisinin/piperaquine drug pressure increases. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3201/eid2401.170864 |
It is part of: | Emerging Infectious Diseases, 2018, vol. 24, num. 1, p. 40-48 |
URI: | http://hdl.handle.net/2445/119078 |
Related resource: | http://dx.doi.org/10.3201/eid2401.170864 |
ISSN: | 1080-6040 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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