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http://hdl.handle.net/2445/120942
Title: | GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment |
Author: | Miranda i Rius, Jaume Brunet i Llobet, Lluís Lahor i Soler, Eduard Dios-Miranda, David de Giménez Rubio, Josep Anton |
Keywords: | Maloclusió Apnea Trastorns del creixement Inflamació Malocclusion Apnea Growth disorders Inflammation |
Issue Date: | 10-May-2017 |
Publisher: | BioMed Central |
Abstract: | Background: A link between progressive dental malocclusion, the use of a continuous positive airway pressure mask and GH-secreting pituitary macroadenoma (acromegaly) has not been previously reported. The present clinicopathological analysis stresses that tooth malposition should not be seen exclusively as a local process. Case Presentation: A 62-year-old caucasian man with no relevant medical history reported difficulty chewing food and perceived voice alteration during his annual periodontal check-up. He also referred stiffness of the tongue, face, and submandibular area. The patient had been diagnosed with obstructive sleep apnea syndrome two years previously, since when he had worn a continuous positive airway pressure device during sleep. Exploration of the occlusion revealed significant changes: an atypical left lateral and anterior open bite with major buccoversion of teeth 33, 34, 35, 36. Inspection of the soft tissue revealed only macroglossia, although external palpation indicated a subcutaneous stiffness of the submandibular area. General analytical tests, including hormone profiles, and magnetic resonance imaging confirmed the diagnosis of acromegaly induced by a pituitary adenoma. Intrasellar tumor resection via transsphenoidal approach was performed. After surgery, the patient already noted a marked improvement of all symptoms associated with the acromegaly. Desaturation data also evolved favourably and the pulmonologist advised the patient to abandon the continuous positive airway pressure treatment. Conclusion: Progressive dental malocclusion may be associated with a systemic disease and the use of a nasal mask with premaxillary support may distort the diagnosis of acromegaly. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13005-017-0140-6 |
It is part of: | Head & Face Medicine, 2017, vol. 13, num. 7 |
URI: | http://hdl.handle.net/2445/120942 |
Related resource: | https://doi.org/10.1186/s13005-017-0140-6 |
ISSN: | 1746-160X |
Appears in Collections: | Articles publicats en revistes (Odontoestomatologia) |
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