El CRAI romandrà tancat del 24 de desembre de 2025 al 6 de gener de 2026. La validació de documents es reprendrà a partir del 7 de gener de 2026.
El CRAI permanecerá cerrado del 24 de diciembre de 2025 al 6 de enero de 2026. La validación de documentos se reanudará a partir del 7 de enero de 2026.
From 2025-12-24 to 2026-01-06, the CRAI remain closed and the documents will be validated from 2026-01-07.
 

Articles publicats en revistes (Odontoestomatologia)

URI permanent per a aquesta col·leccióhttps://hdl.handle.net/2445/20726

 Estadístiques

Examinar

Enviaments recents

Mostrant 1 - 20 de 1543
  • Miniatura
    logoOpenAccessArticle
    Pain, duration and safety of computer-assisted surgical exposure of palatally displaced canines: A case series
    (Medicina Oral SL, 2025-10-14) Lara Muros, María; Rosa Gay, María Cristina de la; Vilarrasa, Javi; García Mira, Berta; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo; Camps Font, Octavi
    Background: Surgical guides have recently been introduced in application to the open exposure of palatally displaced canines (PDCs). The present study assesses postoperative pain, fitting of the guide, surgery time and safety of the procedure. Material and methods: A prospective case-series was conducted from March 2023 to October 2024. Patients 12 to 20 years of age with at least one PDC requiring treatment with a combined orthodontic fixed appliances and surgical approach were included. Surgical templates were obtained after virtual planning. An intraoral scan was superimposed with cone-beam computed tomography to design the guide with a window according to the canine position. Flapless open exposure using the guide was performed, employing a scalpel and ostectomy with burs if needed. Surgery time (from the administration of local anesthesia to the start of the orthodontic attachment bonding or the placement of the protective pack), guide adjustment and intra-surgical complications were also reported. A questionnaire was given to the patient to record postoperative pain, analgesic consumption and any possible adverse event. Descriptive and bivariate analyses were performed.RESULTS: Ten patients (14 PDCs) were included. Computer-assisted PDC exposure lasted a median of 26 minutes (IQR = 18.00), and no complications were reported. All patients experienced mild post-operative pain (i.e., VAS < 40 mm). Pain intensity peaked between 2 and 24 hours post-surgery and gradually decreased over time. Surgical guides successfully fit in all cases. No fitting issues were noted that affected the accurate placement or functionality of the guide. Conclusions: Computer-guided exposure of PDCs is a feasible minimally invasive approach that reduces surgery time and postoperative pain. The use of an individualized guide is an easy tool for increasing the safety and efficacy of this procedure.
  • Miniatura
    logoOpenAccessArticle
    Knowledge about peri-implant diseases in fifth year dental students of the University of Barcelona (Spain): A cross-sectional study
    (Medicina Oral SL, 2025-08-01) Terradellas-Luengo, Anna; García-García, Marta; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo; Sánchez Torres, Alba
    Background: The replacement of missing teeth with implants is a frequent procedure in dental practice, and is usually associated with high implant survival rates. Peri-implant diseases are very common, however. It is therefore essential for clinicians to periodically examine and evaluate implant-supported restorations. The main objective of the present study was to evaluate the level of knowledge about peri-implant diseases and determine the possible associations with demographic variables in fifth year dental students of the University of Barcelona (Spain). Material and methods: A cross-sectional study of the knowledge about peri-implant diseases was carried out using a survey administered to the fifth year dental students of the University of Barcelona. Descriptive and bivariate analyses using the Student t-test and Pearson correlation coefficient were made. The significance level was set at p < 0.05. Results: Eighty-three students were included in the study. A mean of 8.7 points (correct answers) were recorded out of a total of 15 possible points. Good student knowledge was observed in relation to prevention and risk factors. No significant associations were observed between the number of correct answers and the different variables studied. Almost all the students (95.2%) underscored the need for further training in peri-implant diseases. Conclusions: Fifth year students have average level knowledge about peri-implant diseases, with good mastery of prevention and risk factors. There is a general perception that knowledge about prevention and risk factors and the treatment of peri-implant diseases is not enough. In addition, the students are aware of their shortcomings and recognize the need for further training in this field.
  • Miniatura
    logoOpenAccessArticle
    Chronic kidney disease and chronic oral inflammatory diseases: A systematic review and meta-analysis of periodontitis and apical periodontitis
    (MDPI, 2025-11-10) López Sanz, Laura; León López, Maria; Egido-Moreno, Sonia; Segura Raya, Carlos; López López, José, 1958-; Segura Sampedro, Juan J.; Cabanillas Balsera, Daniel; Segura Egea, Juan José
    Background: Chronic kidney disease (CKD) has been increasingly associated with oral chronic inflammatory conditions, including periodontitis (PD) and apical periodontitis (AP). Both share common pathophysiological pathways involving systemic inflammation, immune dysregulation, and oxidative stress. This systematic review and meta-analysis aimed to synthesize current evidence on the association between CKD and chronic oral inflammatory diseases. Methods: The PRISMA guidelines were followed and the proto-col was registered in PROSPERO: CRD420251167323. A comprehensive electronic search was conducted in PubMed, Scopus, Web of Science, and ProQuest up to September 2025. Observational studies reporting prevalence of chronic oral inflammatory diseases in CKD patients and controls subjects were included. The Newcastle-Ottawa scale was used for assessing risk of bias. Pooled odds ratios (ORs) were calculated using a random-effects model. Results: Seven studies published between 2011 and 2025, including 13,139 participants, met the inclusion criteria. CKD patients had significantly higher prevalence of oral inflammatory disease than controls (OR = 4.2; 95% CI = 2.5-7.2; p < 0.00001). Heterogeneity was high (I2 = 83.0%). Subgroup analysis showed an OR of 4.3 (95% CI = 2.6-7.0; p < 0.0001) for AP and 4.3 (95% CI = 2.2-8.7) for PD. The overall risk of bias was moderate, and the certainty of evidence according to GRADE was rated as low. Conclusions This systematic review and meta-analysis highlight a potential link between chronic oral inflammatory disease, including both AP and PD, and chronic kidney disease (CKD). However, the certainty of the evidence is low, and substantial heterogeneity exists across studies.
  • Miniatura
    logoOpenAccessArticle
    A novel technique for computer-assisted dental autotransplantation: A case report with 42 months of follow-up
    (Tabriz University of Medical Sciences (TUOMS), 2025-04-13) Chegeni, Ehsan; Marques, José; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo; Kadkhodazadeh, Mahdi
    Dental autotransplantation (DAT) is an effective technique for replacing missing teeth. This case report presents a novel computer-assisted approach using cone-beam computed tomography (CBCT) for 3D planning. A 15-year-old female with a hopeless molar due to failed endodontic treatment underwent DAT. Following 3D planning, the donor tooth was surgically extracted and transplanted into the prepared socket, followed by semi-rigid splinting. A meticulous 42-month clinical and radiographic follow-up demonstrated the success and stability of the procedure. This innovative method emphasizes the role of advanced computer technology and 3D imaging in enhancing surgical precision and treatment outcomes. Within the limitations of this case report, DAT, combined with computer-assisted planning, proved a reliable and predictable treatment option for replacing hopeless teeth, particularly in young patients. This approach showed the potential of DAT to transform tooth replacement strategies with better accuracy and decision-making.
  • Miniatura
    logoOpenAccessArticle
    Is there really a relationship between maxillary and mandibular incisor inclination and the amount of surrounding cortical alveolar bone? A systematic review
    (BioMed Central, 2025-09-02) d'Oliveira, Nuno Gustavo; Monill González, Anna; Valle-Cañada, Pau; Albaladejo, Alberto; Curto, Adrián
    Background: For orthodontists, the position of the incisors is a key factor in setting treatment goals. Achieving maximum stability requires that they be positioned in the medullary portion of the alveolar bone, balanced with the lingual and labial musculature. Incorrect orthodontic movements can result in root resorption, dehiscences, or even fenestrations. Methods: A systematic review of the bibliography was conducted in accordance with PRISMA recommendations. Searches were made in PubMed, Scopus, and Cochrane Library databases, using the same search terms in each, with no limitation on publication data, up to July 1st, 2024. The review accepted articles in any language. Randomized controlled trials, case-control studies, and cohort studies were included, both retrospective and prospective. Systematic reviews, meta-analyses, case reports, case series, literature reviews, and editorials were excluded. The quality of the articles was determined according to the CONSORT criteria. Results: The initial database search identified 167 articles: 89 in PubMed, 74 in Scopus, and 4 in the Cochrane Library. Of these, 75 were duplicates, leaving 92. After applying the inclusion criteria, a total of 8 articles were included in this systematic review. Conclusions: This systematic review highlights the significant relationship between alveolar bone thickness and incisor inclination as assessed by CBCT. The bone thickness varies regionally, with the maxilla generally having thicker palatal bone and the mandible having thinner labial bone. CBCT is indispensable for evaluating cases involving severe skeletal discrepancies, preexisting bone defects, or planned movements beyond the alveolar limits, while traditional methods may suffice for less complex cases. Standardizing methodologies and conducting longitudinal studies with diverse populations are crucial for improving clinical guidelines and ensuring safe, effective treatment planning.
  • Miniatura
    logoOpenAccessArticle
    Accuracy of a dynamic guided surgery system for orthodontic miniscrew placement: an experimental in vitro study
    (The Angle Orthodontist (EH Angle Education & Research Foundation), 2025-07-14) Moya Martínez, Tania; Figueiredo, Rui; Jorba García, Adrià; Bara Casaus, José Javier; Rojas Vizcaya, Fernando; Rosa Gay, María Cristina de la; Sánchez Torres, Alba; Valmaseda Castellón, Eduardo
    Objectives To compare the accuracy and time required for orthodontic miniscrew placement using a dynamic computer-assisted surgery (d-CAS) system vs the conventional freehand (FH) approach. The effect of side, location, and operator experience was also evaluated. Materials and Methods A randomized, in vitro experimental study was conducted using 10 maxillary resin models. After virtual planning, 40 miniscrews were randomly placed by one experienced and one novice operator. Twenty miniscrews were placed using a d-CAS system (test group) and 20 using the conventional FH method (control group). Preoperative and postoperative cone beam computed tomography scans were superimposed to measure deviations between the planned and final miniscrew position, and placement time was recorded. Results The d-CAS group showed less deviation at the entry point (95% confidence interval [CI] = 1.79 mm to 0.16 mm; P = .019) and less angle deviation (95% CI = 8.5 degrees to 1.7 degrees; P = .004). No significant differences were observed in other variables. Both operators achieved similar accuracy. Placement time was significantly longer in the d-CAS group, with a mean difference of 6.3 minutes (P < .001). Conclusions Dynamic computer-assisted surgery improves the accuracy of orthodontic miniscrew placement vs the traditional FH method. However, d-CAS takes significantly longer. Clinician experience does not seem to significantly affect accuracy.
  • Miniatura
    logoOpenAccessArticle
    Accuracy of Miniscrew Insertion with Fully Guided Dynamic Navigation Versus Freehand: An In Vitro Experimental Study
    (MDPI AG, 2025-10-31) De-la-rosa-gay, Cristina; Mesalles Cervera, David; Jorba García, Adrià ; Ruiz-Romero, Víctor ; Moya-Martinez, Tania ; Camps Font, Octavi ; Crego Ruiz, Marina ; Valmaseda Castellón, Eduardo; Figueiredo, Rui
    The placement of miniscrews in orthodontics enhances dental and skeletal movements with reduced need for patient cooperation but may lead to complications such as incorrect positioning or damage to adjacent teeth. Computer-assisted surgery techniques have shown improved accuracy and reduced risks. This study aimed to compare the accuracy of the X-Guide (R) dynamic navigation system with the freehand method for orthodontic miniscrew insertion and to assess the influence of screw position and side on accuracy. The main hypothesis was that the X-Guide (R) system would yield superior accuracy in the primary variable (3D apical deviation) compared to the freehand technique. Secondary hypotheses were that the X-Guide (R) system would also demonstrate superior accuracy in the secondary parameters (3D entry deviation, angular deflection, apical depth, and 2D entry deviation) and that screw position and side would not significantly affect any of the outcomes. An in vitro, randomized, and blinded experimental design was used with 10 maxillary models divided into two groups: experimental (X-Guide (R)) and control (freehand). In each model, six miniscrews were planned using cone beam computed tomography (CBCT): three were inserted freehand and three with navigation. A trained novice clinician performed all insertions. Post-placement CBCT scans were used to compare 3D deviations between planned and actual positions. Wilcoxon signed-rank tests and Friedman's ANOVA were applied. In conclusion, the results supported the main hypothesis regarding the primary variable: the X-Guide (R) system significantly improved miniscrew placement accuracy in terms of 3D apical deviation, even when used by a novice operator. However, the results partially rejected the secondary hypotheses related to precision, showing a significant improvement in 3D entry deviation with dCAS, but not in angular deflection or 2D measured parameters. Furthermore, the results supported the secondary hypothesis regarding screw position, which did not affect the outcomes. Nevertheless, with dCAS, a significantly greater deviation was found on the right side for 3D entry deviation, 2D entry deviation, and angular deflection.
  • Miniatura
    logoOpenAccessArticle
    Evaluating the efficacy of digitally fabricated prostheses in enhancing oral function and aesthetics among elderly patients: A clinical and colorimetric analysis
    (Power System Technology, 2025-08-22) Torné Duran, Sergi
    La incorporación de la tecnología digital en la odontología protésica ha revolucionado significativamente la producción de prótesis completas, especialmente en pacientes de edad avanzada. Las prótesis fabricadas digitalmente son traumáticas, con resultados funcionales y estéticos potencialmente mejores, ya que los pacientes mayores presentan casos difíciles para la rehabilitación oral. Objetivo: Este estudio analiza el rendimiento clínico y estético de las prótesis fabricadas digitalmente en términos de efectividad y mejora en la función de los pacientes de edad avanzada, con especial referencia a las mejoras funcionales y la precisión del color. Métodos: Se utilizó un diseño clínico y observacional, que incorporó a personas mayores edéntulas a quienes se les colocó prótesis completas diseñadas digitalmente. Se realizaron mediciones cuantitativas para evaluar el rendimiento funcional y decorativo (pruebas de eficiencia masticatoria y medidas de resultados reportadas por el paciente [PROM], respectivamente) y la precisión colorimétrica mediante espectrofotometría y métodos estandarizados para evaluar la coincidencia de color. Este análisis estadístico se incluyó en una evaluación comparativa con los flujos de trabajo de fabricación tradicional. Resultados: Los resultados mostraron una mayor satisfacción del paciente, una mayor eficiencia masticatoria en las prótesis dentales fabricadas digitalmente que en las convencionales, y una mayor precisión en la correspondencia del color. Tras pruebas de envejecimiento prematuro, la estabilidad del color no superó los límites aceptables en el ámbito clínico. Conclusión: Las prótesis fabricadas digitalmente ofrecen a los pacientes mayores una prótesis sólida, estable y visualmente atractiva. Su introducción en la odontología geriátrica está contribuyendo a mejores resultados en la rehabilitación y se integran en el futuro de la prostodoncia centrada en el paciente.
  • Miniatura
    logoOpenAccessArticle
    Efficacy of midazolam in outpatient pediatric dentistry: A systematic review
    (Wiley, 2025-10-21) Rabassa Blanco, Judit; Cahuana-Bartra, Pau; González Chópite, Yndira; Rocha Eiroa, Maria Dolores; Ramírez Rámiz, Albert; Mashala, Elias Isaack; Brunet i Llobet, Lluís; Miranda i Rius, Jaume
    Aims: The aim of this systematic review was to analyze the efficacy, advantages and adverse effects of midazolam in outpatient pediatric dentistry. Methods: This review was carried out in accordance with the PRISMA criteria. A systematic electronic search was conducted through MEDLINE/PubMed, Scopus, and the Cochrane Library databases up to September 2024. An advanced and reproducible search strategy was used to identify relevant studies. Articles were excluded if they focused solely on midazolam as a premedication for general anesthesia or elective surgery, involving patients with special diseases. Inclusion criteria required participants aged 0-16 years, patients with behavioral and/or cooperation disorders and undergoing simple dental restorative procedures under local anesthesia, such as fillings, pulp therapies, stainless steel crowns, or basic extractions. Patients with specific medical conditions, as well as those who were not monitored for vital signs during sedation, were excluded from the study. The risk of bias assessment was analyzed using the criteria set out in the Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. Results: A total of 28 studies were included in the analysis, which were conducted across 11 countries and involved a total of 4374 children aged between 2 and 14 years. Most studies demonstrated a low risk of bias. Many of the participants were ASA I or II status and were assessed using behavioral scales, primarily the Frankl scale. Twelve adjunct drugs were combined with midazolam, and various administration routes were explored, including oral, intranasal, and buccal. Dosing protocols varied, as did fasting guidelines prior to sedation. Outcome measures included vital sign monitoring and behavioral assessments, most commonly via the Houpt and MOAA/S scales. Midazolam generally proved effective in reducing anxiety and improving cooperation, with reported benefits extending to future dental visits. Adverse effects were infrequently noted and typically mild, including nausea, vomiting, and paradoxical reactions. Conclusions: Midazolam has been shown to be an effective and safe agent for moderate sedation in pediatric dental procedures when administered orally at a dose range of 0.3-0.5 mg/kg. The evidence suggests that it reliably reduces anxiety and improves cooperation. Supervision, preferably by an anesthesiologist, is recommended when combined with other drugs to ensure patient safety.
  • Miniatura
    logoOpenAccessArticle
    Cytotoxicity and cytokine expression induced by silorane and methacrylate-based composite resins
    (Faculdade de Odontologia de Bauru, Universidade de São Paulo, 2016-07-01) Longo, Daniele Lucca; Paula-Silva, Francisco Wanderley G.; Faccioli, Lucia H.; Gatón Hernández, Patrícia; Queiroz, Alexandra Mussolino de; Silva, Léa Assed Bezerra da
    Objective: The aim of this study was to evaluate cytotoxicity and cytokine production induced by light-cured or non-light-cured methacrylate-based and silorane composite resins in RAW 264.7 macrophages. Material and methods: Cells were stimulated with the extracts from light-cured or non-light-cured composite resins. After incubation for 24 h, cytotoxicity was assessed with the lactate dehydrogenase (LDH) and methyl thiazolyl tetrazolium (MTT) assays, and total protein was quantified using the Lowry method. TNF-α detection was examined with an enzyme-linked immunosorbent assay (ELISA) conducted with cell supernatants after cell stimulation for 6, 12, and 24 h. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's post hoc test (α=0.05). Results: KaloreTM and FiltekTM Silorane were cytotoxic with or without light curing (p<0.05) after 24 h of incubation. KaloreTM stimulated the early production of TNF-α in comparison with control (p<0.05), whereas FiltekTM Silorane did not affect TNF-α levels after 6 and 12 h (p>0.05). However, after 24 h FiltekTM Silorane inhibited the production of TNF-α (p<0.05). Conclusions: KaloreTM and FiltekTM Silorane were cytotoxic regardless of light curing. The extract obtained from KaloreTM after 15 days of incubation stimulated the production of TNF-α, unlike that obtained from FiltekTM Silorane.
  • Miniatura
    logoOpenAccessArticle
    Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
    (MDPI, 2025-08-20) Wiench, Rafal; Fiegler-Rudol, Jakub; Grzech-Leśniak, Kinga; Skaba, Dariusz; Arnabat Domínguez, Josep
    Antimicrobial resistance is a critical global health issue exacerbated by biofilm-associated infections that often resist conventional therapies. Photodithazine-mediated antimicrobial photodynamic therapy (PDZ-aPDT) has emerged as a promising alternative, demonstrating a broad-spectrum antimicrobial efficacy against multidrug-resistant bacteria and fungi, including those in biofilms. This systematic review evaluates the efficacy, safety, and clinical applications of PDZ-aPDT by synthesizing evidence from preclinical and clinical studies. Databases including PubMed, Embase, Scopus, and Cochrane were systematically searched, resulting in the inclusion of 13 studies for qualitative analysis. PDZ-aPDT consistently reduced the microbial burden in various models, including oral candidiasis, denture stomatitis, acne, and infections related to medical devices. Synergistic combinations with conventional antimicrobials and adjunctive therapies (e.g., DNase I) further enhanced its effectiveness. However, the evidence base remains limited by methodological variability, small sample sizes, and short follow-up periods. Future research should focus on rigorous clinical trials with standardized protocols and extended follow-up to establish definitive efficacy and safety profiles, facilitating a broader clinical implementation in combating antimicrobial resistance.
  • Miniatura
    logoOpenAccessArticle
    Glossary of Computer-Assisted Implant Surgery and Related Terms. First Edition
    (Wiley, 2025-08-11) Jorba García, Adrià; Pozzi, Alessandro; Chen, Zhuofan; Chow, James; Doliveux, Romain; Leung, Yiu Yan; Maruo, Katsuhiro; Pimkhaokham, Atiphan; Sadilina, Sofya; Siu, Adam; Vietor, Kay; Wang, Feng; Wu, Yiqun; Yi, Man; Al-Nawas, Bilal; Mattheos, Nikos; Abrahamsson, Peter; Anderud, Jonas; Arunjaroensuk, Sirida; Balmer, Mark; Bornstein, Michael; Camps Font, Octavi; Chen, Jinyan; Kai Yu, Aaron Chu; Correia, André; Couso-Queiruga, Emilio; Dittmar, Roman; Fehmer, Vincent; Barbosa de Figueiredo, Rui Pedro; Guentsch, Arndt; Hamilton, Adam; Herweg, Holger; Janda, Martin; Joda, Tim; Jung, Ronald; Kungsadalpipob, Kajorn; Kunz, Pascal; Lambert, France; Lanis, Alexander; Larsson, Christel; Malarik, Remo; Mangano, Francesco Guido; Messo, Elias; Pelekos, George; Murat Kokat, Ali; Raabe, Clemens; Rungsiyakull, Pimduen; Sailer, Irena; Shahdad, Shakeel; Stavropoulos, Andreas; Strauss, Franz; Subbalekha, Keskanya; Suwanwela, Jaijam; Tao, Baoxin; Thieringer, Florian M.; Thoma, Daniel S.; Uei, Lin Jing; Valmaseda Castellón, Eduardo; Wismeijer, Daniel; Yeo, Boon Kang Alvin; Yeo, Xin Hui
    The rapid development of computer-assisted implant surgery (CAIS) and the respective research and clinical applications have necessitated a standardization of the terminology related not only to different devices, but also the different steps involved, surgical and presurgical procedures. The present glossary was introduced at the 1st International Team for Implantology Symposium on Computer-assisted Implant Surgery, based on the collective work of clinicians and researchers with deep understanding and experience in these technologies. The glossary was further refined and revised through the structured input of a large group of global experts within clinical application, research, and education of CAIS. The glossary includes 98 terms organized in 5 domains, aiming to clarify ambiguity and propose some standard nomenclature in the service of clinical practice, research but also development of new devices, protocols, and approaches.
  • Miniatura
    logoOpenAccessArticle
    Impact of autoclaving on the dimensional stability of 3D-Printed surgical guides for aesthetic crown lengthening
    (MDPI, 2025-08-02) González-Barnadas, Albert; Ribas-Garcia, Anna; Jorba García, Adrià; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo; Camps Font, Octavi
    The aim of this study was to evaluate the impact of autoclaving on the dimensional stability of surgical guides (SGs) for aesthetic crown lengthening (ACL) using different resins/printing methods. Fifty SGs for ACL were printed using five different resin/printer combinations (FL, SR, ND, KS and VC). All the SGs were scanned before (T0) and after (T1) sterilization. Autoclaving was conducted at 134 °C during 4 min. The STL files of each SG at T0 and T1 were compared with the original design (TR). Dimensional stability was measured using trueness and precision. Deviations from TR to T1 were calculated in the three space axes and by measuring the area between three reference landmarks. At T0, the FL group showed the best trueness and precision, while the SR group performed significantly worse than the other groups. At T1, all the groups except VC exhibited significant dimensional alterations compared with T0. Also, VC showed the best trueness and precision values. All the groups had a significant deviation in at least one space axis, while only the SR group exhibited significant variations from T1 to TR in the area between the reference landmarks. Most of the evaluated resin/3D printer combinations suffered significant dimensional alterations after autoclaving.
  • Miniatura
    logoOpenAccessArticle
    Influence of implant-supported prosthesis design on peri-implant health: a cross-sectional study.
    (Medicina Oral SL, 2025-08-16) Alahmari, Ahmad; Barbosa de Figueiredo, Rui Pedro; García-García, Marta; Mir-Marí, Javier; Valmaseda Castellón, Eduardo; Sánchez Torres, Alba
    Backgroun: Peri-implant diseases are common complications that may lead to dental implant failure. An adequate prosthesis design is crucial to reduce the risk of complications, and to improve peri-implant health. The present study was carried out to assess the effect of prosthesis design upon the presence of peri-implant inflammation. Material and methods: A cross-sectional study was conducted in patients with a single-unit implant-supported screw-retained crown. After removing the crowns, standardized photographs were made to assess several variables such as the length of the submucosal extension (SE) or the emergence angle (EA). Clinical signs of inflammation were also registered, and an experienced clinician probed the implants. The White (WES) and Pink Esthetic Scores (PES) were also recorded. Patients were classified into two groups according to the presence (positive bleeding on probing (BoP+)) or absence (negative bleeding on probing (BoP-)) of inflammation around the dental implant. Independent t-tests and one-way ANOVA were used to analyze the data. Results: A total of 90 implants were analyzed. Fifty-two implants (57.8%) had BoP+ while 38 (42.2%) had no signs of inflammation of the peri-implant tissues (BoP-). Long SE was significantly associated with BoP+ sites. The EA did not seem to be related to the presence of inflammation (p=0.642). PES/WES showed a negative correlation with buccal EA (r=-0.227; p=0.032). Conclusions: Long submucosal extensions in single-unit implant-supported crowns seem to be associated with peri-implant tissues inflammation (BoP+). A higher emergence angle on the buccal aspect was associated with poor esthetic outcomes.
  • Miniatura
    logoOpenAccessArticle
    Impact of implant-abutment connection design on biological and mechanical outcomes in posterior single-tooth restorations: A randomized clinical trial
    (Elsevier, 2025-07-15) Rubianes-Porta, Laura; Traver Méndez, Valeria; Ghiorghiu, Roxanna; Piera-Auguet, Jordi; Subirà Pifarré, Carles; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo; Camps Font, Octavi
    Statement of problem: The implant-abutment interface has been identified as a key factor in preserving peri-implant marginal bone levels. However, current evidence remains insufficient to identify the most suitable connection design since most published studies fail to control critical variables such as the implant surface or design. Purpose: The purpose of this randomized clinical trial was to assess vertical marginal bone loss after 1 year of function of implants with identical macroscopic and microscopic designs and 3 different implant-abutment connections (external hexagon, internal hexagon, and conical) placed in the molar or premolar area. The secondary aims were to assess the mechanical and biological complications after 1 year of function. Material and methods: An open-label, randomized controlled trial with 3 treatment arms was carried out. Participants were assessed at implant placement, prosthesis installation, and after 1 year of loading. The main outcome variable was the distance from the implant shoulder to the marginal bone at the mesial and distal aspect of each implant. Probing depth, plaque index, and bleeding on probing, as well as mechanical or biological complications, were also assessed. A descriptive, bivariate and multivariate analysis (linear models and binary logistic models) of the data was performed. Results: Seventy-five participants with 105 implants were consecutively enrolled and randomized to the external hexagon, internal hexagon, and conical connection groups (35 implants each). The 3 groups had similar baseline features. The distance from the implant shoulder to the marginal bone varied significantly over time (P<.001) but was similar for all groups (P=.152) and followed the same evolution pattern over time (P=.995). Seven failures in 7 participants were registered during the study (3 in external hexagon, 1 in internal hexagon, and 3 in conical connection (P=.356). Conclusions: The implant-abutment connection design did not significantly affect the changes in interproximal bone levels of posterior single-unit implant-supported crowns after 12 months of loading. Furthermore, the risk of developing biological or mechanical complications was similar for all the tested connection designs.
  • Miniatura
    logoOpenAccessArticle
    Improving evaluation of dentistry students in an oral surgery and implantology subject: The PIETA rubric
    (John Wiley & Sons, 2025-12-01) Rosa Gay, María Cristina de la; Camps Font, Octavi; Sánchez Torres, Alba; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo
    Introduction: The objectives were to design an online rubric for fourth-year Dentistry students in the subject of Clinical Oral Surgery and Implantology and to compare the results with the grades of the written exam. Material and methods: A general rubric (PIETA) was designed and started in the academic year 2022-2023, and was tested in 2023-2024. The PIETA rubric evaluated punctuality and interest, assessed with a reflective diary (PI component) and empathy, technique and autonomy (ETA component). Teachers only marked the rubric when a change was perceived, either as improvement or worsening, to avoid repetitive feedback. Final assessment of the clinical work was carried out with the last score of the rubric to enhance student engagement. Evolution of ETA scores at 3 time points (initial, intermediate and final sessions) was analysed with a generalised estimating function (GEE). Rubric scores and written exam grades were correlated with Pearson's correlation. Results: The PIETA rubric was used by 10 clinical assistants to assess 102 students in 2023-2024. The mean number of procedures evaluated was 77.3 (standard deviation [SD] = 37.0) per assistant and 7.6 (SD = 2.5) per student. The PI and ETA components showed a significant positive correlation. The ETA score significantly increased from the first to the last session (p < 0.001). While the PI component did not correlate with the written exam grades, the ETA component showed a significant positive correlation with the outcomes of the written exam in both academic years. Conclusions: The PIETA rubric is easy to use, improves transparency, reduces student complaints of unfair evaluation, and provides immediate feedback after clinical practice. The devil is in the details: feedback and frequency of evaluations should be monitored regularly.
  • Miniatura
    logoOpenAccessArticle
    Comprehensive update on implants in patients with head and neck cancer (2021–2024): systematic review and meta-analysis of the impact of radiotherapy and chemotherapy on implant survival
    (John Wiley & Sons, 2025-12-01) Schiegnitz, Eik; Fan, Shengchi; Diaz, Leonardo; Sáenz-Ravello, Gustavo; Valmaseda Castellón, Eduardo; Al-Nawas, Bilal
    Objectives: This study aimed to investigate implant outcomes in patients with head and neck cancer undergoing radiotherapy or chemotherapy by incorporating the latest research findings. Methods: The present review was conducted to update the focused question: What is the survival rate of implants placed in patients with head and neck cancer receiving radiotherapy or chemotherapy compared to non-irradiated patients? It built upon two previous systematic reviews (2014 and 2022) and provided an updated synthesis of the literature, focusing on clinical studies published between 2021 and 2024. The earlier reviews were included in the quantitative synthesis only to offer a broader longitudinal perspective. Results: Nine studies were identified, with seven included in the quantitative synthesis and meta-analysis. The implant survival rate was significantly lower in irradiated patients (85.6%) compared to non-irradiated patients (90.0%) (RR = 1.62, 95% CI: 1.33-1.98, p < 0.0001, I2 = 0.2%). Additionally, implant failure risk was higher in grafted bone (RR = 2.03, 95% CI: 1.39-2.96, p = 0.0018, I2 = 21.9%) than in native bone. Among irradiated patients, those receiving radiochemotherapy exhibited an even greater risk of implant failure (RR = 1.97, 95% CI: 1.09-3.56, p = 0.0331, I2 = 0%) compared to non-irradiated patients. Conclusions: Current evidence indicates that radiotherapy/chemotherapy significantly increases the risk of implant loss in patients with head and neck cancer, with higher radiation doses possibly being associated with increased peri-implant bone loss, while implants placed in native bone exhibit a lower risk of failure compared to those placed in grafted bone.
  • Miniatura
    logoOpenAccessArticle
    Reconstructive therapy in patients with peri-implantitis in a university dental hospital: a preliminary retrospective case series focusing on complications
    (MDPI, 2025-07-01) Alahmari, Ahmad; Costa-Berenguer, Xavier; Barbosa de Figueiredo, Rui Pedro; Valmaseda Castellón, Eduardo; Sánchez Torres, Alba; García-García, Marta
    Peri-implantitis is an inflammatory disease-causing bone loss around dental implants, often requiring reconstructive surgical therapies to reduce probing depth and regenerate bone. However, such surgeries are frequently complicated by postoperative issues. This retrospective case series aimed to identify the main postoperative complications following the reconstructive treatment of peri-implant bone defects in peri-implantitis patients. Data from 14 patients with 21 affected implants were analyzed, including demographics, oral hygiene, surgical techniques, and complications such as wound dehiscence, membrane exposure, and infections. Wound dehiscence was measured using Image J® software version 1.54. Descriptive and bivariate analyses were performed. The results showed that 11 implants (52.4%; 95% confidence interval (95%CI): 29% to 76%) in nine patients (57.1%; 95%CI = 27% to 87%) developed soft tissue dehiscence after one week, with membrane exposure observed in 4 implants. Dehiscence was significantly associated with mandibular implant location (p = 0.003), poor interproximal hygiene (p = 0.008), and membrane exposure (p = 0.034). No postoperative infections were recorded. In conclusion, more than half of peri-implantitis patients undergoing reconstructive surgery experience wound dehiscence, particularly in cases involving mandible, poor hygiene, and membrane exposure. This complication might compromise bone regeneration and reduce the treatment success rate. These results should be interpreted cautiously due to study design limitations (retrospective design, lack of a control group, and small sample size).
  • Miniatura
    logoOpenAccessArticle
    In vivo analysis of early biofilm development and cell viability on implant-mimicking abutments at 24 h, 48 h, and 7 days
    (BioMed Central, 2025-12-01) Muguerza-Guevara, Kevin; Cortés Acha, Berta; García-García, Marta; Barbosa de Figueiredo, Rui Pedro; Soler-Ollé, Agnès; Blanc, Vanessa; Valmaseda Castellón, Eduardo
    Introduction: The microbiota associated with peri-implant diseases has been described, though information about biofilm formation and development on dental implants remains scarce. Objectives: To analyze and compare biofilm formation and distribution at 24 h, 48 h and 7 days on experimental abutments simulating dental implants in peri-implant healthy patients. Material and methods: Experimental abutments with micro-threads and a modified rough surface were placed in healthy dental implants of 10 patients. Instructions were given not to clean the abutments for the duration of the study. Exclusion criteria included the use of antiseptics or antibiotics 30 days prior to recruitment or during the study period. After 24 h, 48 h and 7 days, the abutments were removed and stained using LIVE/DEAD stain, and two sides (buccal and palatal/lingual) and two areas (supragingival and subgingival) were assessed, with measurement of the mean biofilm covering area. Results: Twenty-nine experimental abutments placed in 10 patients were assessed. The total mean biomass coverage areas were 9.3%, 16.2% and 16.8% at 24 h, 48 h and 7 days, respectively, with significant differences being observed between 24 h and the subsequent timepoints (p < 0.05). Significantly greater supragingival biofilm coverage was observed at 7 days in comparison with the subgingival zone (21.85% versus 11.7%; p < 0.05). Conclusions: Biofilm coverage on healthy dental implants increases progressively during the first 48 h and then stabilizes. The biofilm is mainly composed of live cells in the supragingival and subgingival areas. After 7 days, the supragingival areas show significantly greater biofilm coverage.
  • Miniatura
    logoOpenAccessArticle
    Rapid reduction of pro-inflammatory cytokines with an oral topical composition comprising olive oil, trimethylglycine and xylitol: a randomized double-blind controlled trial
    (MDPI, 2025-05-21) López López, José, 1958-; Reuss, José M.; Vinuesa Aumedes, Teresa; Egido-Moreno, Sonia; Roselló Llabrés, Xavier; Pereira-Riveros, Tanya; Reuss, Debora; Alonso-Gamo, Laura; Rodríguez-Vilaboa, Beatriz
    An underlying pro-inflammatory status is related to recurrence and persistence of inflammatory susceptibility in obesity and periodontitis, two of the most prevalent chronic inflammatory diseases. Elevated levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), part of the inflammatory network linking these two conditions, persist even after periodontal treatment, with high salivary cytokine levels being linked to overweight and obesity risk. This trial assessed the effect of a novel composition comprising olive oil, trimethylglycine and xylitol, delivered topically to the oral mucosa, on salivary cytokines in periodontally healthy normal and overweight/pre-obese individuals. In a randomized placebo-controlled double-blind clinical trial, adult patients were randomly assigned to use a test toothpaste (intervention group, IG) or a placebo toothpaste (control group, CG) three times a day for 1 month. Primary outcomes were levels of salivary cytokines IL-1β, TNF-α and interleukin-4 (IL-4). Significant differences between IG and CG were observed for IL-1β (p = 0.003; Z = 2.901; r = 0.62) and TNF-α (p = 0.001; Z = 3.23; r = 0.69), but not for IL-4 (p = 0.203; Z = 1.321; r = 0.28). A significant reduction in IL-1β (p = 0.008) and a near significant reduction in TNF-α (p = 0.059) was found in the IG at the end of the trial. Additionally, the effect of body mass index on cytokine levels response was analyzed. A significantly different behavior was shown between IG and CG in the overweight/pre-obesity subgroup for IL-1β (p = 0.014; Z = 2.430; r = 0.63) and TNF-α (p = 0.029; Z = 2.199; r = 0.57). Moreover, a significant decrease in IL-1β in the IG (p = 0.028) was observed. The rapid reduction in IL-1β and TNF-α after 1 month of use of the intervention composition suggests a safe and effective novel strategy for reducing pro-inflammatory cytokines that may offer an opportunity to diminish the inflammatory status in patients with overweight/pre-obesity.