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Title: Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
Author: Casas Rodríguez, Rosa M.
Urpí Sardà, Mireia
Sacanella Meseguer, Emilio
Arranz Martínez, Sara
Corella Piquer, Dolores
Castañer, Olga
Lamuela Raventós, Rosa Ma.
Salas Salvadó, Jordi
Lapetra, José
Portillo, María P.
Estruch Riba, Ramon
Keywords: Cuina mediterrània
Malalties cardiovasculars
Mediterranean cooking
Cardiovascular diseases
Issue Date: 18-Apr-2017
Publisher: Hindawi Publishing Corporation
Abstract: Objective. To evaluate the long-Term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group. Conclusions. Long-Term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
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It is part of: Mediators of Inflammation, 2017, vol. 2017, num. 3674390
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ISSN: 0962-9351
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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