Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/121775
Title: | Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
Author: | Moncunill, Gemma Mayor Aparicio, Alfredo Gabriel Jiménez, Alfons Nhabomba, Augusto J. Puyol, Laura Manaca, Maria Nélia Barrios, Diana Cisteró, Pau Guinovart, Caterina Aguilar, Ruth Bardají, Azucena Pinazo, Maria-Jesus Angov, Evelina Dutta, Sheetij Chitnis, Chetan E. Muñoz, José Gascón i Brustenga, Joaquim Dobaño, Carlota, 1969- |
Keywords: | Citoquines Malària Plasmodium falciparum Cytokines Malaria Plasmodium falciparum |
Issue Date: | 21-Feb-2013 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0055756 |
It is part of: | PLoS One, 2013 |
URI: | http://hdl.handle.net/2445/121775 |
Related resource: | https://doi.org/10.1371/journal.pone.0055756 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
679595.pdf | 378.12 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License