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http://hdl.handle.net/2445/122309
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DC Field | Value | Language |
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dc.contributor.author | Hillion, Joëlle | - |
dc.contributor.author | Canals Buj, Meritxell | - |
dc.contributor.author | Torvinen, Maria | - |
dc.contributor.author | Casadó, Vicent | - |
dc.contributor.author | Scott, Rizaldy | - |
dc.contributor.author | Terasmaa, Anton | - |
dc.contributor.author | Hansson, Anita | - |
dc.contributor.author | Watson, Stanley | - |
dc.contributor.author | Olah, Mark E. | - |
dc.contributor.author | Mallol Montero, Josefa | - |
dc.contributor.author | Canela Campos, Enric I. | - |
dc.contributor.author | Zoli, Michele | - |
dc.contributor.author | Agnati, Luigi F. | - |
dc.contributor.author | Ibanez, Carlos F. | - |
dc.contributor.author | Lluís i Biset, Carme | - |
dc.contributor.author | Franco Fernández, Rafael | - |
dc.contributor.author | Ferré, Sergi | - |
dc.contributor.author | Fuxe, Kjell | - |
dc.date.accessioned | 2018-05-11T13:59:15Z | - |
dc.date.available | 2018-05-11T13:59:15Z | - |
dc.date.issued | 2002-05 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122309 | - |
dc.description.abstract | Antagonistic and reciprocal interactions are known to exist between adenosine and dopamine receptors in the striatum. In the present study, double immunofluorescence experiments with confocal laser microscopy showed a high degree of colocalization of adenosine A(2A) receptors (A(2A)R) and dopamine D(2) receptors (D(2)R) in cell membranes of SH-SY5Y human neuroblastoma cells stably transfected with human D(2)R and in cultured striatal cells. A(2A)R/D(2)R heteromeric complexes were demonstrated in coimmunoprecipitation experiments in membrane preparations from D(2)R-transfected SH-SY5Y cells and from mouse fibroblast Ltk(-) cells stably transfected with human D(2)R (long form) and transiently cotransfected with the A(2A)R double-tagged with hemagglutinin. Long term exposure to A(2A)R and D(2)R agonists in D(2)R-cotransfected SH-SY5Y cells resulted in coaggregation, cointernalization and codesensitization of A(2A)R and D(2)R. These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Biochemistry and Molecular Biology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1074/jbc.M107731200 | - |
dc.relation.ispartof | Journal of Biological Chemistry, 2002, vol. 277, num. 20, p. 18091-18097 | - |
dc.relation.uri | https://doi.org/10.1074/jbc.M107731200 | - |
dc.rights | (c) American Society for Biochemistry and Molecular Biology, 2002 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.classification | Malalties del sistema nerviós | - |
dc.subject.classification | Adenosina | - |
dc.subject.other | Cell receptors | - |
dc.subject.other | Nervous system Diseases | - |
dc.subject.other | Adenosine | - |
dc.title | Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 501595 | - |
dc.date.updated | 2018-05-11T13:59:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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501595.pdf | 607.29 kB | Adobe PDF | View/Open |
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