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http://hdl.handle.net/2445/123114
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DC Field | Value | Language |
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dc.contributor.author | Subirats i Vila, Xavier | - |
dc.contributor.author | Redón, Lídia | - |
dc.contributor.author | Rosés Pascual, Martí | - |
dc.date.accessioned | 2018-06-19T12:24:47Z | - |
dc.date.available | 2018-06-19T12:24:47Z | - |
dc.date.issued | 2018-04-06 | - |
dc.identifier.issn | 1848-7718 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123114 | - |
dc.description.abstract | In the present study apressure-assisted MEEKC method with reversed-polarity using a conventional CE instrument with UV detection and uncoated fused silica capillariesis validated as a high-throughput methodology for the lipophilicity determination of the neutral species of acidic compounds(pKa> 3.5).After the calibration of the system with four standard compoundsof known log Po/w, mass distribution ratios (log kMEEKC) of new molecules can be directly converted into log Po/wvalues by means of a simple linear equation (log Po/w=a·log kMEEKC+b). The method was internally and externally validated for a log Po/wrange between-1.54 and4.75, with higheraccuraciesthan conventional liquid chromatographic methods. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IAPC Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.5599/admet.491 | - |
dc.relation.ispartof | ADMET & DMPK, 2018, vol. 6, num. 2, p. 153-161 | - |
dc.relation.uri | https://doi.org/10.5599/admet.491 | - |
dc.rights | cc-by (c) Subirats i Vila, Xavier et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Electroforesi capil·lar | - |
dc.subject.classification | Cromatografia de líquids | - |
dc.subject.classification | Lipofília | - |
dc.subject.other | Capillary electrophoresis | - |
dc.subject.other | Liquid chromatography | - |
dc.subject.other | Lipophilicity | - |
dc.title | Lipophilicity determination of acidic compounds: MEEKC as a reliable high-throughput methodology | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 680765 | - |
dc.date.updated | 2018-06-19T12:24:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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File | Description | Size | Format | |
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680765.pdf | 892.29 kB | Adobe PDF | View/Open |
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