Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/123114
Title: | Lipophilicity determination of acidic compounds: MEEKC as a reliable high-throughput methodology |
Author: | Subirats i Vila, Xavier Redón, Lídia Rosés Pascual, Martí |
Keywords: | Electroforesi capil·lar Cromatografia de líquids Lipofília Capillary electrophoresis Liquid chromatography Lipophilicity |
Issue Date: | 6-Apr-2018 |
Publisher: | IAPC Publishing |
Abstract: | In the present study apressure-assisted MEEKC method with reversed-polarity using a conventional CE instrument with UV detection and uncoated fused silica capillariesis validated as a high-throughput methodology for the lipophilicity determination of the neutral species of acidic compounds(pKa> 3.5).After the calibration of the system with four standard compoundsof known log Po/w, mass distribution ratios (log kMEEKC) of new molecules can be directly converted into log Po/wvalues by means of a simple linear equation (log Po/w=a·log kMEEKC+b). The method was internally and externally validated for a log Po/wrange between-1.54 and4.75, with higheraccuraciesthan conventional liquid chromatographic methods. |
Note: | Reproducció del document publicat a: https://doi.org/10.5599/admet.491 |
It is part of: | ADMET & DMPK, 2018, vol. 6, num. 2, p. 153-161 |
URI: | http://hdl.handle.net/2445/123114 |
Related resource: | https://doi.org/10.5599/admet.491 |
ISSN: | 1848-7718 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
680765.pdf | 892.29 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License