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http://hdl.handle.net/2445/123491
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DC Field | Value | Language |
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dc.contributor.author | Ma, Xing | - |
dc.contributor.author | Jannasch, Anita | - |
dc.contributor.author | Albrecth, Urban-Raphael | - |
dc.contributor.author | Hahn, Kersten | - |
dc.contributor.author | Miguel López, Albert | - |
dc.contributor.author | Schäffer, Erik | - |
dc.contributor.author | Sánchez Ordóñez, Samuel | - |
dc.date.accessioned | 2018-07-11T13:56:47Z | - |
dc.date.available | 2018-07-11T13:56:47Z | - |
dc.date.issued | 2015-10-14 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123491 | - |
dc.description.abstract | The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications. | ca |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1021/acs.nanolett.5b03100 | - |
dc.relation.ispartof | Nano Letters, 2015, vol. 15, num. 10, p. 7043-7050 | - |
dc.relation.uri | http://dx.doi.org/10.1021/acs.nanolett.5b03100 | - |
dc.rights | (c) American Chemical Society, 2015 | - |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Sílice | - |
dc.subject.classification | Nanopartícules | - |
dc.subject.classification | Enzims | - |
dc.subject.other | Silica | - |
dc.subject.other | Nanoparticles | - |
dc.subject.other | Enzymes | - |
dc.title | Enzyme-powered hollow mesoporous Janus nanomotors | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/311529/EU//LT-NRBS | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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L21_2015_Nano Letters_15_7043.pdf | 4.14 MB | Adobe PDF | View/Open |
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