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Title: | Enzyme-powered hollow mesoporous Janus nanomotors |
Author: | Ma, Xing Jannasch, Anita Albrecth, Urban-Raphael Hahn, Kersten Miguel López, Albert Schäffer, Erik Sánchez Ordóñez, Samuel |
Keywords: | Sílice Nanopartícules Enzims Silica Nanoparticles Enzymes |
Issue Date: | 14-Oct-2015 |
Publisher: | American Chemical Society |
Abstract: | The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1021/acs.nanolett.5b03100 |
It is part of: | Nano Letters, 2015, vol. 15, num. 10, p. 7043-7050 |
URI: | http://hdl.handle.net/2445/123491 |
Related resource: | http://dx.doi.org/10.1021/acs.nanolett.5b03100 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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File | Description | Size | Format | |
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L21_2015_Nano Letters_15_7043.pdf | 4.14 MB | Adobe PDF | View/Open |
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