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http://hdl.handle.net/2445/123494
Title: | Interrogating open issues in cancer precision medicine with patient-derived xenografts |
Author: | Byrne, Annette T. Alférez, Denis G. Amant, Frédéric Annibali, Daniela Arribas, Joaquín V. (Vicente) Biankin, Andrew V. Bruna, Alejandra Budinská, Eva Caldas, Carlos Chang, David K. Clarke, Robert B. Clevers, Hans Coukos, George Dangles Marie, Virginie Eckhardt, S. Gail González Suárez, Eva Hermans, Els Hidalgo, Manuel Jarzabek, Monika A. Jong, Steven de Jonkers, Jos Kemper, Kristel Lanfrancone, Luisa Mælandsmo, Gunhild Mari Marangoni, Elisabetta Marine, Jean-Christophe Medico, Enzo Norum, Jens Henrik Palmer, Héctor G. Peeper, Daniel S. Pelicci, Pier Giuseppe Piris Gimenez, Alejandro Roman Roman, Sergio Rueda, Oscar M. Seoane Suárez, Joan Serra, Violeta Soucek, Laura Vanhecke, Dominique Villanueva Garatachea, Alberto Vinolo, Emilie Bertotti, Andrea Trusolino, Livio |
Keywords: | Càncer Marcadors tumorals Cancer Tumor markers |
Issue Date: | 20-Jan-2017 |
Publisher: | Springer Nature |
Abstract: | Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1038/nrc.2016.140 |
It is part of: | Nature Reviews Cancer, 2017, vol. 17, p. 254–268 |
URI: | http://hdl.handle.net/2445/123494 |
Related resource: | http://dx.doi.org/10.1038/nrc.2016.140 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Byrne_et_al_NRC_2018.pdf | 1.84 MB | Adobe PDF | View/Open |
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