Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/123832
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Garza Puentes, Andrea de la | - |
dc.contributor.author | Montes Goyanes, Rosa | - |
dc.contributor.author | Chisaguano Tonato, Aida Maribel | - |
dc.contributor.author | Torres Espinola, Francisco José | - |
dc.contributor.author | Arias García, Miriam | - |
dc.contributor.author | de Almeida, Leonor | - |
dc.contributor.author | Bonilla Aguirre, María | - |
dc.contributor.author | Guerendiain Margni, Marcela Esther | - |
dc.contributor.author | Castellote Bargalló, Ana Isabel | - |
dc.contributor.author | Segura Moreno, Maite | - |
dc.contributor.author | García-Valdés, Luz | - |
dc.contributor.author | Campoy, Cristina | - |
dc.contributor.author | López Sabater, María del Carmen | - |
dc.contributor.author | PREOBE Team | - |
dc.date.accessioned | 2018-07-24T08:12:33Z | - |
dc.date.available | 2018-07-24T08:12:33Z | - |
dc.date.issued | 2017-06-09 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123832 | - |
dc.description.abstract | Single nucleotide polymorphisms (SNPs) in the genes encoding the fatty acid desaturase (FADS) and elongase (ELOVL) enzymes affect long-chain polyunsaturated fatty acid (LC-PUFA) production. We aimed to determine if these SNPs are associated with body mass index (BMI) or affect fatty acids (FAs) in pregnant women. Participants (n = 180) from the PREOBE cohort were grouped according to pre-pregnancy BMI: normal-weight (BMI = 18.5-24.9, n = 88) and overweight/obese (BMI≥25, n = 92). Plasma samples were analyzed at 24 weeks of gestation to measure FA levels in the phospholipid fraction. Selected SNPs were genotyped (7 in FADS1, 5 in FADS2, 3 in ELOVL2 and 2 in ELOVL5). Minor allele carriers of rs174545, rs174546, rs174548 and rs174553 (FADS1), and rs1535 and rs174583 (FADS2) were nominally associated with an increased risk of having a BMI≥25. Only for the normal-weight group, minor allele carriers of rs174537, rs174545, rs174546, and rs174553 (FADS1) were negatively associated with AA:DGLA index. Normal-weight women who were minor allele carriers of FADS SNPs had lower levels of AA, AA:DGLA and AA:LA indexes, and higher levels of DGLA, compared to major homozygotes. Among minor allele carriers of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher DHA:EPA index than the normal-weight group; however, they did not present higher DHA concentrations than the normal-weight women. In conclusion, minor allele carriers of FADS SNPs have an increased risk of obesity. Maternal weight changes the effect of genotype on FA levels. Only in the normal-weight group, minor allele carriers of FADS SNPs displayed reduced enzymatic activity and FA levels. This suggests that women with a BMI≥25 are less affected by FADS genetic variants in this regard. In the presence of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher n-3 LC-PUFA production indexes than women with normal weight, but this was not enough to obtain a higher n-3 LC-PUFA concentration. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0179135 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 6, p. 1-16 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0179135 | - |
dc.rights | cc-by (c) de la Garza Puentes, Andrea et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Embarassades | - |
dc.subject.classification | Pes corporal | - |
dc.subject.classification | Àcids grassos | - |
dc.subject.classification | Genètica | - |
dc.subject.other | Pregnant women | - |
dc.subject.other | Body weight | - |
dc.subject.other | Fatty acids | - |
dc.subject.other | Genetics | - |
dc.title | Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 677184 | - |
dc.date.updated | 2018-07-24T08:12:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28598979 | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
677184.pdf | 1.54 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License