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http://hdl.handle.net/2445/124064| Title: | Genome-wide association study of colorectal cancer identifies six new susceptibility loci |
| Author: | Fredrick R. Schumacher Schmit, Stephanie L. Jiao, Shuo Edlund, Christopher K. Wang, Hansong Zhang, Ben Hsu, Li Huang, Shu-Chen Fischer, Christopher P. Harju, John F. Idos, Gregory E. Lejbkowicz, Flavio Manion, Frank J. McDonnell, Kevin McNeil, Caroline E. Melas, Marilena Rennert, Hedy S. Shi, Wei Thomas, Duncan C. Berg, David J. Van den Hutter, Carolyn M. Aragaki, Aaron K. Butterbach, Katja Caan, Bette J. Carlson, Christopher S. Chanock, Stephen J. Curtis, Keith R. Fuchs, Charles S. Gala, Manish Giovannucci, Edward L. Gogarten, Stephanie M. Hayes, Richard B. Henderson, Brian E. Hunter, David J. Jackson, Rebecca D. J. Kolonel, Laurence N. Kooperberg, Charles Küry, Sébastien LaCroix, Andrea Moreno Aguado, Víctor |
| Keywords: | Càncer colorectal Genoma humà Genètica Colorectal cancer Human genome Genetics |
| Issue Date: | 7-Jul-2015 |
| Publisher: | Nature Publishing Group |
| Abstract: | Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies. |
| Note: | El document inclou una pàgina final amb una correcció (corrigendum). Aquesta, per si sola, té el següent DOI: 10.1038/ncomms9739 i es va publicar al mateix vol. 6. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1038/ncomms8138 |
| It is part of: | Nature Communications, 2015, vol. 6, num. 7138, p. 1-6 |
| URI: | http://hdl.handle.net/2445/124064 |
| Related resource: | https://doi.org/10.1038/ncomms8138 |
| ISSN: | 2041-1723 |
| Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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