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Title: | Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins |
Author: | Muñoz Soriano, Verónica Domingo Muelas, Ana Li, Tianlu Gamero, Esther Bizy, Alexandra Fariñas, Isabel Alepuz, Paula Paricio, Nuria |
Keywords: | Cèl·lules eucariotes Citosquelet Eukaryotic cells Cytoskeleton |
Issue Date: | 29-Aug-2017 |
Publisher: | Nature Publishing |
Abstract: | Elongation factor eIF5A is required for the translation of consecutive prolines, and was shown in yeast to translate polyproline-containing Bni1, an actin-nucleating formin required for polarized growth during mating. Here we show that Drosophila eIF5A can functionally replace yeast eIF5A and is required for actin-rich cable assembly during embryonic dorsal closure (DC). Furthermore, Diaphanous, the formin involved in actin dynamics during DC, is regulated by and mediates eIF5A effects. Finally, eIF5A controls cell migration and regulates Diaphanous levels also in mammalian cells. Our results uncover an evolutionary conserved role of eIF5A regulating cytoskeleton-dependent processes through translation of formins in eukaryotes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-10057-y |
It is part of: | Scientific Reports, 2017, vol. 7 |
URI: | http://hdl.handle.net/2445/124281 |
Related resource: | https://doi.org/10.1038/s41598-017-10057-y |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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Munoz-SorianoV.pdf | 3.24 MB | Adobe PDF | View/Open |
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