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Title: Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Author: Palacín, Arantxa
Gómez Casado, Cristina
Rivas, Luis A.
Aguirre, Jacobo
Tordesillas, Leticia
Bartra Tomàs, Joan
Blanco, Carlos
Carrillo, Teresa
Cuesta Herranz, Javier
Frutos, Consolación de
García Álvarez-Eire, Genoveva
Fernández, Francisco J.
Gamboa, Pedro
Muñoz, Rosa
Sánchez-Monge, Rosa
Sirvent, Sofía
Torres, María J.
Varela Losada, Susana
Rodríguez, Rosalía
Parro, Victor
Blanca, Miguel
Salcedo, Gabriel
Díaz Perales, Araceli
Keywords: Al·lèrgens
Proteïnes vegetals
Plant proteins
Issue Date: 14-Dec-2012
Publisher: Public Library of Science (PLoS)
Abstract: The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 12, p. e50799
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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