Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124909
Title: | Toward angiogenesis inhibitors based on the conjugation of organometallic platinum(II) complexes to RGD peptides |
Author: | Zamora, Ana Gandioso, Albert Massaguer i Vall-llovera, Anna Buenestado, Silvia Calvis, Carme Hernández, José Luis Mitjans, Francesc Rodríguez, Venancio Ruiz, José Marchán Sancho, Vicente |
Keywords: | Angiogènesi Càncer Pèptids Compostos organometàl·lics Neovascularization Cancer Peptides Organometallic compounds |
Issue Date: | 6-Sep-2018 |
Publisher: | Wiley-VCH |
Abstract: | A novel conjugate between a cyclometalated platinum(II) complex with dual antiangiogenic and antitumor activity and a cyclic peptide containing the RGD sequence (-Arg-Gly-Asp-) has been synthesized by combining solid- and solution-phase methodologies. Although peptide conjugation rendered a non-cytotoxic compound in all tested tumor cell lines (± αV β3 and αV β5 integrin receptors), the antiangiogenic activity of the Pt-c(RGDfK) conjugate in human umbilical vein endothelial cells at sub-cytotoxic concentrations opens the way to the design of a novel class of angiogenesis inhibitors through conjugation of metallodrugs with high antiangiogenic activity to cyclic RGD-containing peptides or peptidomimetic analogues. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/cmdc.201800282 |
It is part of: | ChemMedChem, 2018, vol. 13, num. 17, p. 1755-1762 |
URI: | http://hdl.handle.net/2445/124909 |
Related resource: | https://doi.org/10.1002/cmdc.201800282 |
ISSN: | 1860-7179 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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