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DC Field | Value | Language |
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dc.contributor.author | Lesseur, Corina | - |
dc.contributor.author | Diergaarde, Brenda | - |
dc.contributor.author | Olshan, Andrew F. | - |
dc.contributor.author | Wünsch-Filho, Victor | - |
dc.contributor.author | Ness, Andrew R. | - |
dc.contributor.author | Liu, Geoffrey | - |
dc.contributor.author | Lacko, Martin | - |
dc.contributor.author | Eluf Neto, José | - |
dc.contributor.author | Franceschi, Silvia | - |
dc.contributor.author | Lagiou, Pagona | - |
dc.contributor.author | MacFarlane, Gary J. | - |
dc.contributor.author | Richiardi, Lorenzo | - |
dc.contributor.author | Boccia, Stefania | - |
dc.contributor.author | Polesel, Jerry | - |
dc.contributor.author | Kjaerheim, Kristina | - |
dc.contributor.author | Zaridze, David | - |
dc.contributor.author | Johansson, Mattias | - |
dc.contributor.author | Menezes, Ana A. | - |
dc.contributor.author | Curado, Maria Paula | - |
dc.contributor.author | Robinson, Max | - |
dc.contributor.author | Ahrens, Wolfgang | - |
dc.contributor.author | Canova, Cristina | - |
dc.contributor.author | Znaor, Ariana | - |
dc.contributor.author | Castellsagué, Xavier | - |
dc.contributor.author | Conway, David I. | - |
dc.contributor.author | Holcátová, Ivana | - |
dc.contributor.author | Mates, Dana | - |
dc.contributor.author | Vidensky, Marta | - |
dc.contributor.author | Healy, Claire M. | - |
dc.contributor.author | Szeszenia-Dabrowska, Neonila | - |
dc.contributor.author | Fabianova, Eleonora | - |
dc.contributor.author | Lissowska, Jolanta | - |
dc.contributor.author | Grandis, Jennifer R. | - |
dc.contributor.author | Weissler, Mark C. | - |
dc.contributor.author | Tajara, Eloiza H. | - |
dc.contributor.author | Nunes, Fabio D. | - |
dc.contributor.author | Carvalho, Marcos B. de | - |
dc.contributor.author | Thomas, Steve | - |
dc.contributor.author | Hung, Rayjean J. | - |
dc.contributor.author | Peters, Wilbert H. M. | - |
dc.contributor.author | Herrero, Rolando | - |
dc.contributor.author | Cadoni, Gabriella | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Steffen, Annika | - |
dc.contributor.author | Agudo, Antonio | - |
dc.contributor.author | Shangina, Oxana | - |
dc.contributor.author | Xiao, Xiangjun | - |
dc.contributor.author | Gaborieau, Valérie | - |
dc.contributor.author | Chabrier, Amélie | - |
dc.contributor.author | Anantharaman, Devasena | - |
dc.contributor.author | Boffetta, Paolo | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | McKay, James D. | - |
dc.contributor.author | Brennan, Paul | - |
dc.date.accessioned | 2018-10-16T13:04:47Z | - |
dc.date.available | 2018-10-16T13:04:47Z | - |
dc.date.issued | 2016-12-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125359 | - |
dc.description.abstract | We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3685 | - |
dc.relation.ispartof | Nature Genetics, 2016, vol. 48, num. 12, p. 1544-1550 | - |
dc.relation.uri | https://doi.org/10.1038/ng.3685 | - |
dc.rights | cc-by-nc-sa (c) Lesseur et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de boca | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.other | Oral cancer | - |
dc.subject.other | Papillomaviruses | - |
dc.title | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T12:15:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27749845 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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LesseurC.pdf | 1.68 MB | Adobe PDF | View/Open |
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