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Title: | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer |
Author: | Lesseur, Corina Diergaarde, Brenda Olshan, Andrew F. Wünsch-Filho, Victor Ness, Andrew R. Liu, Geoffrey Lacko, Martin Eluf Neto, José Franceschi, Silvia Lagiou, Pagona MacFarlane, Gary J. Richiardi, Lorenzo Boccia, Stefania Polesel, Jerry Kjaerheim, Kristina Zaridze, David Johansson, Mattias Menezes, Ana A. Curado, Maria Paula Robinson, Max Ahrens, Wolfgang Canova, Cristina Znaor, Ariana Castellsagué, Xavier Conway, David I. Holcátová, Ivana Mates, Dana Vidensky, Marta Healy, Claire M. Szeszenia-Dabrowska, Neonila Fabianova, Eleonora Lissowska, Jolanta Grandis, Jennifer R. Weissler, Mark C. Tajara, Eloiza H. Nunes, Fabio D. Carvalho, Marcos B. de Thomas, Steve Hung, Rayjean J. Peters, Wilbert H. M. Herrero, Rolando Cadoni, Gabriella Bueno de Mesquita, H. Bas Steffen, Annika Agudo, Antonio Shangina, Oxana Xiao, Xiangjun Gaborieau, Valérie Chabrier, Amélie Anantharaman, Devasena Boffetta, Paolo Amos, Christopher I. McKay, James D. Brennan, Paul |
Keywords: | Càncer de boca Papil·lomavirus Oral cancer Papillomaviruses |
Issue Date: | 1-Dec-2016 |
Publisher: | Nature Publishing Group |
Abstract: | We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3685 |
It is part of: | Nature Genetics, 2016, vol. 48, num. 12, p. 1544-1550 |
URI: | http://hdl.handle.net/2445/125359 |
Related resource: | https://doi.org/10.1038/ng.3685 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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