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https://hdl.handle.net/2445/125709
Title: | Trisomy 8, A Cytogenetic Abnormality In Myelodysplastic Syndromes, Is Constitutional Or Not? |
Author: | Saumell, Sílvia Solé Ristol, Francesc Arenillas Rocha, Leonor Montoro, Julia Valcárcel, David Pedro, Carme Sanzo, Carmen Luño, Elisa Giménez, Teresa Arnan, Montserrat Pomares, Helena Paz, Raquel de Arrizabalaga, Beatriz Jerez, Andrés Marténez, Ana B. Sánchez Castro, Judith Rodríguez Gambarte, Juan D. Raya, José Maria Ríos, Eduardo Rodríguez Rivera, María Espinet Solà, Blanca Florensa, Lourdes |
Keywords: | Leucèmia mieloide Limfòcits Myeloid leukemia Lymphocytes |
Issue Date: | 12-Jun-2015 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Isolated trisomy 8 is not considered presumptive evidence of myelodysplastic syndrome (MDS) in cases without minimal morphological criteria. One reason given is that trisomy 8 (+8) can be found as a constitutional mosaicism (cT8M). We tried to clarify the incidence of cT8M in myeloid neoplasms, specifically in MDS, and the diagnostic value of isolated +8 in MDS. Twenty-two MDS and 10 other myeloid neoplasms carrying +8 were studied. Trisomy 8 was determined in peripheral blood by conventional cytogenetics (CC) and on granulocytes, CD3+ lymphocytes and oral mucosa cells by fluorescence in situ hybridization (FISH). In peripheral blood CC, +8 was seen in 4/32 patients. By FISH, only one patient with chronic myelomonocytic leukemia showed +8 in all cell samples and was interpreted as a cT8M. In our series +8 was acquired in all MDS. Probably, once discarded cT8M by FISH from CD3+ lymphocytes and non-hematological cells, +8 should be considered with enough evidence to MDS. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0129375 |
It is part of: | PLoS One, 2015, vol. 10, num. 6, p. e0129375 |
URI: | https://hdl.handle.net/2445/125709 |
Related resource: | https://doi.org/10.1371/journal.pone.0129375 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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