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DC Field | Value | Language |
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dc.contributor.author | Luque Gómez, Ana | - |
dc.contributor.author | Farwati, Abduljalil | - |
dc.contributor.author | Crovetto, Francesca | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.contributor.author | Figueras Retuerta, Francesc | - |
dc.contributor.author | Gratacós Solsona, Eduard | - |
dc.contributor.author | Aran Perramon, Josep M. | - |
dc.date.accessioned | 2018-11-08T14:40:06Z | - |
dc.date.available | 2018-11-08T14:40:06Z | - |
dc.date.issued | 2014-05-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125922 | - |
dc.description.abstract | To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 early preeclampsia patients, requiring delivery before 34 weeks of gestation, and 44 uncomplicated pregnancies using microfluidic arrays. Among a total of 754 miRNAs analyzed, the presence of 63 miRNAs (8%) was consistently documented in the sera from preeclampsia and control samples. Nevertheless, only 15 amplified miRNAs (2%) seemed to be differentially, although modestly, represented (fold change range: 0.4-1.4). After stem loop RT-qPCR from individual samples, the statistical analysis confirmed that none of the most consistent and differentially represented miRNAs (3 overrepresented and 4 underrepresented) were differentially abundant in serum from preeclamptic pregnancies compared with serum from normal pregnancies. Therefore, maternal serum miRNA assessment at first-trimester of pregnancy does not appear to have any predictive value for early preeclampsia. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep04882 | - |
dc.relation.ispartof | Scientific Reports, 2014, vol. 4 | - |
dc.relation.uri | https://doi.org/10.1038/srep04882 | - |
dc.rights | cc-by (c) Luque Gómez, Ana et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Hipertensió en l'embaràs | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.other | Hypertension in pregnancy | - |
dc.subject.other | MicroRNAs | - |
dc.title | Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 677834 | - |
dc.date.updated | 2018-11-08T14:40:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24811064 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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