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Title: | Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy |
Author: | Luque Gómez, Ana Farwati, Abduljalil Crovetto, Francesca Crispi Brillas, Fàtima Figueras Retuerta, Francesc Gratacós Solsona, Eduard Aran Perramon, Josep M. |
Keywords: | Hipertensió en l'embaràs Micro RNAs Hypertension in pregnancy MicroRNAs |
Issue Date: | 8-May-2014 |
Publisher: | Nature Publishing Group |
Abstract: | To assess the usefulness of circulating microRNAs (miRNAs) as non-invasive molecular biomarkers for early prediction of preeclampsia, a differential miRNA profiling analysis was performed in first-trimester pooled sera from 31 early preeclampsia patients, requiring delivery before 34 weeks of gestation, and 44 uncomplicated pregnancies using microfluidic arrays. Among a total of 754 miRNAs analyzed, the presence of 63 miRNAs (8%) was consistently documented in the sera from preeclampsia and control samples. Nevertheless, only 15 amplified miRNAs (2%) seemed to be differentially, although modestly, represented (fold change range: 0.4-1.4). After stem loop RT-qPCR from individual samples, the statistical analysis confirmed that none of the most consistent and differentially represented miRNAs (3 overrepresented and 4 underrepresented) were differentially abundant in serum from preeclamptic pregnancies compared with serum from normal pregnancies. Therefore, maternal serum miRNA assessment at first-trimester of pregnancy does not appear to have any predictive value for early preeclampsia. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/srep04882 |
It is part of: | Scientific Reports, 2014, vol. 4 |
URI: | http://hdl.handle.net/2445/125922 |
Related resource: | https://doi.org/10.1038/srep04882 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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