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Title: Do nutritional supplements have a role in age macular degeneration prevention?
Author: Pinazo Durán, María Dolores
Gómez Ulla, Francisco
Arias Barquet, Lluís
Araiz, Javier
Casaroli Marano, Ricardo Pedro
Gallego Pinazo, Roberto
García Medina, Jose J.
López Gálvez, María Isabel
Manzanas, Lucía
Salas, Anna
Zapata, Miguel
Díaz Llopis, Manuel
García Layana, Alfredo
Keywords: Malalties de la retina
Suplements nutritius
Retinal diseases
Dietary supplements
Issue Date: 23-Jan-2014
Publisher: Hindawi
Abstract: Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (omega-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and omega-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of omega-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and omega-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.
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It is part of: Journal of Ophthalmology, 2014, vol. 2014
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ISSN: 2090-004X
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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