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http://hdl.handle.net/2445/126452
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DC Field | Value | Language |
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dc.contributor.author | González-Costello, José | - |
dc.contributor.author | Armstrong, Hilary F. | - |
dc.contributor.author | Jorde, Ulrich P. | - |
dc.contributor.author | Bevelaqua, Anna C. | - |
dc.contributor.author | Letarte, Laurie | - |
dc.contributor.author | Thomashow, Byron M. | - |
dc.contributor.author | Bartels, Matthew N. | - |
dc.date.accessioned | 2018-11-27T08:55:29Z | - |
dc.date.available | 2018-11-27T08:55:29Z | - |
dc.date.issued | 2013-08-15 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126452 | - |
dc.description.abstract | We evaluated the prevalence of chronotropic incompetence (CI), a marker of autonomic dysfunction, and its prognostic value in patients with chronic obstructive pulmonary disease (COPD). We performed a retrospective analysis of 449 patients with severe COPD who underwent a cardiopulmonary exercise test, after excluding patients with lung volume reduction surgery, left ventricular dysfunction and those not in sinus rhythm. CI was defined as percent predicted heart rate reserve (%HRR). Events were defined as death or lung transplant during a median follow-up of 68 months. Median age was 61 years; median percent predicted forced expiratory volume in one second (%FEV1) of 25% and median %HRR of 33%. The hazard ratio for an event in the lowest quartile of %HRR, taking the highest quartile as reference, was of 3.2 (95% confidence interval: 2.1-4.8; p < 0.001). In a multivariate regression model, %HRR was an independent predictor of events. In conclusion, Cl was an independent and powerful outcome predictor in patients with severe COPD. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Science | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.resp.2013.05.002 | - |
dc.relation.ispartof | Respiratory Physiology & Neurobiology, 2013, vol. 188, num. 2, p. 113-118 | - |
dc.relation.uri | https://doi.org/10.1016/j.resp.2013.05.002 | - |
dc.rights | (c) Elsevier, 2013 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Mortality | - |
dc.title | Chronotropic incompetence predicts mortality in severe obstructive pulmonary disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T12:47:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23669496 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Gonzalez-CostelloJ.pdf | 282.7 kB | Adobe PDF | View/Open |
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