Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126452
Title: | Chronotropic incompetence predicts mortality in severe obstructive pulmonary disease |
Author: | González-Costello, José Armstrong, Hilary F. Jorde, Ulrich P. Bevelaqua, Anna C. Letarte, Laurie Thomashow, Byron M. Bartels, Matthew N. |
Keywords: | Malalties pulmonars obstructives cròniques Mortalitat Chronic obstructive pulmonary diseases Mortality |
Issue Date: | 15-Aug-2013 |
Publisher: | Elsevier Science |
Abstract: | We evaluated the prevalence of chronotropic incompetence (CI), a marker of autonomic dysfunction, and its prognostic value in patients with chronic obstructive pulmonary disease (COPD). We performed a retrospective analysis of 449 patients with severe COPD who underwent a cardiopulmonary exercise test, after excluding patients with lung volume reduction surgery, left ventricular dysfunction and those not in sinus rhythm. CI was defined as percent predicted heart rate reserve (%HRR). Events were defined as death or lung transplant during a median follow-up of 68 months. Median age was 61 years; median percent predicted forced expiratory volume in one second (%FEV1) of 25% and median %HRR of 33%. The hazard ratio for an event in the lowest quartile of %HRR, taking the highest quartile as reference, was of 3.2 (95% confidence interval: 2.1-4.8; p < 0.001). In a multivariate regression model, %HRR was an independent predictor of events. In conclusion, Cl was an independent and powerful outcome predictor in patients with severe COPD. (C) 2013 Elsevier B.V. All rights reserved. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.resp.2013.05.002 |
It is part of: | Respiratory Physiology & Neurobiology, 2013, vol. 188, num. 2, p. 113-118 |
URI: | http://hdl.handle.net/2445/126452 |
Related resource: | https://doi.org/10.1016/j.resp.2013.05.002 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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