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http://hdl.handle.net/2445/126560
Title: | α-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations |
Author: | Díaz Ramos, M. Àngels Roig Borrellas, Anna García Melero, Ana López Alemany, Roser |
Keywords: | Proteïnes Hidrolases Glucòlisi Proteins Hydrolases Glycolysis |
Issue Date: | 1-Jan-2012 |
Publisher: | Hindawi Publishing Corporation |
Abstract: | α-Enolase is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells and is considered a multifunctional protein. α-enolase is expressed on the surface of several cell types, where it acts as a plasminogen receptor, concentrating proteolytic plasmin activity on the cell surface. In addition to glycolytic enzyme and plasminogen receptor functions, α-Enolase appears to have other cellular functions and subcellular localizations that are distinct from its well-established function in glycolysis. Furthermore, differential expression of α-enolase has been related to several pathologies, such as cancer, Alzheimer’s disease, and rheumatoid arthritis, among others. We have identified α-enolase as a plasminogen receptor in several cell types. In particular, we have analyzed its role in myogenesis, as an example of extracellular remodelling process. We have shown that α-enolase is expressed on the cell surface of differentiating myocytes, and that inhibitors of α-enolase/plasminogen binding block myogenic fusion in vitro and skeletal muscle regeneration in mice. α-Enolase could be considered as a marker of pathological stress in a high number of diseases, performing several of its multiple functions, mainly as plasminogen receptor. This paper is focused on the multiple roles of the α-enolase/plasminogen axis, related to several pathologies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2012/156795 |
It is part of: | Journal of Biomedicine and Biotechnology, 2012, vol. 2012 |
URI: | http://hdl.handle.net/2445/126560 |
Related resource: | https://doi.org/10.1155/2012/156795 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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