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http://hdl.handle.net/2445/126610
Title: | Epigenetic Regulation of miR-212 Expression in Lung Cancer |
Author: | Incoronato, Mariarosaria Urso, Loredana Portela, Anna Laukkanen, Mikko O. Soini, Ylermi Quintavalle, Ylermi Keller, Simona Esteller, Manel Condorelli, Gerolama |
Keywords: | ADN Càncer de pulmó DNA Lung cancer |
Issue Date: | 15-Nov-2011 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0027722 |
It is part of: | PLoS One, 2011, vol. 6, num. 11, p. e27722 |
URI: | http://hdl.handle.net/2445/126610 |
Related resource: | https://doi.org/10.1371/journal.pone.0027722 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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