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https://hdl.handle.net/2445/126898| Title: | Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01 |
| Author: | Vera, Beatriz Martínez Vélez, Naiara Xipell, Enric Acanda de la Rocha, Arlet Patiño García, Ana Saez Castresana, Javier Gonzalez Huarriz, Marisol Cascallò, Manel Alemany Bonastre, Ramon Alonso, Marta M. |
| Keywords: | Glioma Adenovirus Gliomas Adenoviruses |
| Issue Date: | 25-Jan-2016 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0147211 |
| It is part of: | PLoS One, 2016, vol. 11, num. 1, p. e0147211 |
| URI: | https://hdl.handle.net/2445/126898 |
| Related resource: | https://doi.org/10.1371/journal.pone.0147211 |
| Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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