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Title: Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst
Author: Salomó i Prat, Ernest
Gallen Ortiz, Albert
Sciortino, Giuseppe
Ujaque, Gregori
Grabulosa, Arnald
Lledós, Agustí (Lledós i Falcó)
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Catàlisi asimètrica
Enantioselective catalysis
Issue Date: 26-Nov-2018
Publisher: American Chemical Society
Abstract: A novel cationic [IrH(THF)(P,N)(imine)] [BArF] catalyst contg. a P-stereogenic MaxPHOX ligand is described for the direct asym. hydrogenation of N-Me and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile THF ligand allows for effective activation and reactivity, even at low temps. D. functional theory calcns. allowed the rationalization of the stereochem. course of the reaction.
Note: Versió postprint del document publicat a:
It is part of: Journal of the American Chemical Society, 2018, vol. 140, p. 16967-16970
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ISSN: 0002-7863
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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