Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/127180
Title: | Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy |
Author: | Kovacs, Gabor G. Ferrer, Isidro (Ferrer Abizanda) Grinberg, Lea T. Alafuzoff, Irina Attems, Johannes Budka, Herbert Cairns, Nigel J. Crary, John F. Duyckaerts, Charles Ghetti, Bernardino Halliday, Glenda M. Ironside, James W. Love, Seth Mackenzie, Ian R. Muñoz, David G. Murray, Melissa E. Nelson, Peter T. Takahashi, Hitoshi Trojanowski, John Q. Ansorge, Olaf Arzberger, Thomas Baborie, Atik Beach, Thomas G. Bigio, Eileen H. Bodi, Istvan Dugger, Brittany N. Feany, Mel Gelpi, Ellen Gentleman, Stephen M. Giaccone, Giorgio Hatanpaa, Kimmo J. Heale, Richard Hof, Patrick R. Hofer, Monika Hortobágyi, Tibor Jellinger, Kurt Jicha, Gregory A. Ince, Paul Kofler, Julia Kövari, Enikö Bieniek, Kevin F. Kril, Jillian J. Mann, David M. Matej, Radoslav McKee, Ann C. Milenkovic, Ivan Montine, Thomas J. Murayama, Shigeo Lee, Edward B. Rodriguez, Roberta D. Rozemüller, Annemieke Schneider, Julie A. Schultz, Christian Seeley, William W. Seilhean, Danielle Smith, Colin Tagliavini, Fabrizio Takao, Masaki Thal, Dietmar Rudolf Toledo, Jon B. Tolnay, Markus Troncoso, Juan C. Vinters, Harry V. Weis, Serge Wharton, Stephen B. White III, Charles L. McLean, Catriona Rahimi, Jasmin Wisniewski, Thomas Woulfe, John M. Yamada, Masahito Dickson, Dennis W. |
Keywords: | Envelliment cerebral Astròcits Malalties neurodegeneratives Aging brain Astrocytes Neurodegenerative Diseases |
Issue Date: | Jan-2016 |
Publisher: | Springer Verlag |
Abstract: | Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s00401-015-1509-x |
It is part of: | Acta Neuropathologica, 2016, vol. 131, num. 1, p. 87-102 |
URI: | http://hdl.handle.net/2445/127180 |
Related resource: | https://doi.org/10.1007/s00401-015-1509-x |
ISSN: | 0001-6322 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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