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http://hdl.handle.net/2445/127700| Title: | Pd0-Catalyzed Intramoleculara-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines |
| Author: | Solé Arjó, Daniel Pérez Janer, Ferran Mancuso, Raffaella |
| Keywords: | Compostos heterocíclics Compostos de nitrogen Compostos de sofre Pal·ladi (Element químic) Síntesi orgànica Heterocyclic compounds Nitrogen compounds Sulfur compounds Palladium Organic synthesis |
| Issue Date: | 10-Feb-2015 |
| Publisher: | Wiley-VCH |
| Abstract: | A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. KEYWORDS: arylation; domino reactions; nitrogen heterocycles; palladium; sulfones |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1002/chem.201406305 |
| It is part of: | Chemistry-A European Journal, 2015, vol. 21, num. 12, p. 4580-4584 |
| URI: | http://hdl.handle.net/2445/127700 |
| Related resource: | https://doi.org/10.1002/chem.201406305 |
| ISSN: | 0947-6539 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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|---|---|---|---|---|
| 649173.pdf | 373.52 kB | Adobe PDF | View/Open |
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